Kirkwood T B
Department of Geriatric Medicine, University of Manchester, UK.
Bioessays. 1996 Dec;18(12):1009-16. doi: 10.1002/bies.950181211.
Human life expectancy has increased dramatically through improvements in public health, housing, nutrition and general living standards. Lifespan is now limited chiefly by intrinsic senescence and its associated frailty and diseases. Understanding the biological basis of the ageing process is a major scientific challenge that will require integration of molecular, cellular, genetic and physiological approaches. This article reviews progress that has been made to date, particularly with regard to the genetic contribution to senescence and longevity, and assesses the scale of the task that remains.
通过公共卫生、住房、营养和总体生活水平的改善，人类预期寿命已大幅提高。如今，寿命主要受内在衰老及其相关的虚弱和疾病限制。了解衰老过程的生物学基础是一项重大科学挑战，这需要整合分子、细胞、遗传和生理学方法。本文回顾了迄今为止所取得的进展，特别是在衰老和长寿的遗传贡献方面，并评估了仍需完成的任务规模。
