特发性快速进展性肾小球肾炎和血管炎患者血浆置换的回顾性研究
Retrospective study of plasma exchange in patients with idiopathic rapidly progressive glomerulonephritis and vasculitis.
作者信息
Gianviti A, Trompeter R S, Barratt T M, Lythgoe M F, Dillon M J
机构信息
Renal Unit, Hospital for Sick Children, London.
出版信息
Arch Dis Child. 1996 Sep;75(3):186-90. doi: 10.1136/adc.75.3.186.
Abstract
A retrospective study of 48 patients was conducted to evaluate the efficacy of plasma exchange in children with idiopathic rapidly progressive glomerulonephritis (IRPGN), and renal or non-renal vasculitis. All patients were followed up at a single centre over a 15 year period. Treatment consisted of corticosteroids and/or cytotoxic agents. Plasma exchange was used in all patients because of severe renal involvement and/or clinical deterioration. One hundred per cent of patients with renal vasculitis who started plasma exchange within one month of disease onset and 58% of cases with IRPGN had significant improvement in renal function. No relapses of vasculitis were observed after treatment with plasma exchange in patients with renal and non-renal vasculitis. The results suggest that plasma exchange associated with immunosuppressive treatment could be of benefit in cases of IRPGN or vasculitis in terms of both renal and extrarenal recovery.
摘要
对48例患者进行了一项回顾性研究，以评估血浆置换治疗特发性快速进展性肾小球肾炎（IRPGN）及肾性或非肾性血管炎患儿的疗效。所有患者均在单一中心接受了为期15年的随访。治疗包括使用皮质类固醇和/或细胞毒性药物。由于严重的肾脏受累和/或临床病情恶化，所有患者均接受了血浆置换。在疾病发作后1个月内开始进行血浆置换的肾性血管炎患者中，100%肾功能有显著改善，IRPGN患者中有58%也是如此。肾性和非肾性血管炎患者接受血浆置换治疗后均未观察到血管炎复发。结果表明，血浆置换联合免疫抑制治疗对于IRPGN或血管炎患者的肾脏和肾外恢复可能有益。
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