Wessels I F, Randhawa R S
Department of Ophthalmology, Loma Linda University, California, USA.
Eye (Lond). 1996;10 ( Pt 5):620-5. doi: 10.1038/eye.1996.141.
The standard oculokinetic perimetry test (OKP) was modified to present a light blue stimulus on a dark background (MOKP) to determine whether the sensitivity and specificity for detecting glaucomatous visual field loss could be improved. Thirty-five adult glaucoma patients (70 eyes) self-administered both tests and the results were correlated with the loss of retinal sensitivity on the Octopus IV program 38. The MOKP detected 18% more true scotomatous loci (more than 15 dB loss of attenuation) than the standard OKP (p < 0.0001). The gain was due to 37% fewer false negatives (p < 0.0001), but with a doubling of the false positives rate (p < 0.049). With a disease prevalence of approximately 2%, the MOKP and OKP would respectively miss 15% or 30%, and include 14 or 9 normals for each diseased individual. This relatively simple modification may further improve the OKP for detecting glaucoma.
对标准的眼动视野计测试（OKP）进行了改进，在暗背景上呈现浅蓝色刺激（MOKP），以确定检测青光眼性视野缺损的敏感性和特异性是否能够提高。35名成年青光眼患者（70只眼）自行完成了这两种测试，结果与Octopus IV程序38上视网膜敏感性的丧失情况相关。与标准OKP相比，MOKP检测到的真正暗点部位（衰减超过15 dB丧失）多18%（p < 0.0001）。这种增加是由于假阴性减少了37%（p < 0.0001），但假阳性率增加了一倍（p < 0.049）。在疾病患病率约为2%的情况下，MOKP和OKP分别会漏诊15%或30%的患者，并且每发现一名患病个体，会分别将14名或9名正常人误判为患病。这种相对简单的改进可能会进一步提高OKP检测青光眼的能力。
