Dönmez H, Ozkul Y, Uçak R
Department of Medical Biology, Medical Faculty, Erciyes University, Kayseri, Turkey.
Mutat Res. 1996 Dec 12;361(2-3):129-32. doi: 10.1016/s0165-1161(96)90247-2.
Pleural mesothelioma, lung cancer, pleural calcification and fibrosis have been observed among inhabitants of the villages in Ivriz-Zanapa valley in Turkey. Earlier reports have stated that these endemic pathological conditions are caused by the inhalation of actinolite asbestos, a mineral commonly used indiscriminately to paint the walls and floors of houses. In the present study, 40 inhabitants in Yassikaya village in Ivriz-Zanapa valley and 20 controls were further investigated. The peripheral blood lymphocytes were cultured and harvested at 72 h for sister chromatid exchange (SCE) frequency. Inhabitants had a raised mean SCE rate compared with a control population.
在土耳其伊夫里兹-扎纳帕山谷的村庄居民中，已观察到胸膜间皮瘤、肺癌、胸膜钙化和纤维化。早期报告称，这些地方病病理状况是由吸入阳起石石棉所致，阳起石是一种过去常被随意用于房屋墙壁和地板粉刷的矿物。在本研究中，对伊夫里兹-扎纳帕山谷亚西卡亚村的40名居民和20名对照者进行了进一步调查。外周血淋巴细胞培养72小时后收获，用于检测姐妹染色单体交换（SCE）频率。与对照人群相比，居民的平均SCE率有所升高。
