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幽门螺杆菌对冰岛地衣中原地衣硬脂酸的体外敏感性。

In vitro susceptibility of Helicobacter pylori to protolichesterinic acid from the lichen Cetraria islandica.

作者信息

Ingolfsdottir K, Hjalmarsdottir M A, Sigurdsson A, Gudjonsdottir G A, Brynjolfsdottir A, Steingrimsson O

机构信息

Department of Pharmacy, University of Iceland, Reykjavik, Iceland.

出版信息

Antimicrob Agents Chemother. 1997 Jan;41(1):215-7. doi: 10.1128/AAC.41.1.215.

DOI:10.1128/AAC.41.1.215
PMID:8980785
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC163690/
Abstract

With reference to the traditional use of Cetraria islandica (Iceland moss) for relief of gastric and duodenal ulcer, plant extracts were screened for in vitro activity against Helicobacter pylori. (+)-Protolichesterinic acid, an aliphatic alpha-methylene-gamma-lactone, was identified as an active component. The MIC range of protolichesterinic acid, in free as well as salt form, was 16 to 64 micrograms/ml.

摘要

参照冰岛衣（冰岛苔藓）在传统医学中用于缓解胃和十二指肠溃疡的用途，对该植物提取物进行了抗幽门螺杆菌的体外活性筛选。（+）-原地衣硬脂酸，一种脂肪族α-亚甲基-γ-内酯，被鉴定为活性成分。游离形式以及盐形式的原地衣硬脂酸的最低抑菌浓度范围为16至64微克/毫升。

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