马红球菌基因的单加氧酶样序列通过使利福平失活而赋予对该抗生素的抗性增强。
Monooxygenase-like sequence of a Rhodococcus equi gene conferring increased resistance to rifampin by inactivating this antibiotic.
作者信息
Andersen S J, Quan S, Gowan B, Dabbs E R
机构信息
Genetics Department, University of the Witwatersrand, Johannesburg, South Africa.
出版信息
Antimicrob Agents Chemother. 1997 Jan;41(1):218-21. doi: 10.1128/AAC.41.1.218.
Abstract
A DNA clone from Rhodococcus equi conferring low-level rifampin resistance through the ability to inactivate this antibiotic via its decomposition was identified. The iri (inactivation of rifampin) gene consisted of an open reading frame of 1,437 bp encoding a 479-amino-acid sequence strongly resembling those of monooxygenases acting upon phenolic compounds or involved in polyketide antibiotic synthesis. When expressed in Escherichia coli, the gene conferred resistance to a > 50-micrograms/ml concentration of the drug.
摘要
通过一种能分解利福平从而使其失活的能力，鉴定出了来自马红球菌的一个DNA克隆，该克隆赋予低水平的利福平抗性。iri（利福平失活）基因由一个1437 bp的开放阅读框组成，编码一个479个氨基酸的序列，该序列与作用于酚类化合物或参与聚酮类抗生素合成的单加氧酶的序列非常相似。当在大肠杆菌中表达时，该基因赋予对浓度大于50微克/毫升的该药物的抗性。
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