• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
The Vanderbilt Classification System in the evaluation of diabetic retinopathy patients treated with Alredase.用于评估接受阿地酶治疗的糖尿病视网膜病变患者的范德比尔特分类系统。
Trans Am Ophthalmol Soc. 1996;94:433-47; discussion 447-50.
2
A quantitative system to evaluate diabetic retinopathy from fundus photographs.一种用于从眼底照片评估糖尿病视网膜病变的定量系统。
Invest Ophthalmol Vis Sci. 1995 Jan;36(1):174-81.
3
Web-based grading of compressed stereoscopic digital photography versus standard slide film photography for the diagnosis of diabetic retinopathy.基于网络的压缩立体数码摄影与标准幻灯片胶片摄影在糖尿病视网膜病变诊断中的分级比较
Ophthalmology. 2007 Sep;114(9):1748-54. doi: 10.1016/j.ophtha.2006.12.010. Epub 2007 Mar 21.
4
Inhibition of PKC beta by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients.口服鲁伯斯塔林抑制蛋白激酶Cβ耐受性良好，可改善糖尿病患者视网膜血流动力学异常。
Invest Ophthalmol Vis Sci. 2006 Jan;47(1):86-92. doi: 10.1167/iovs.05-0757.
5
Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy.鲁比前列酮对糖尿病视网膜病变患者视力丧失的影响。
Ophthalmology. 2006 Dec;113(12):2221-30. doi: 10.1016/j.ophtha.2006.07.032. Epub 2006 Sep 20.
6
A multicenter, double-blind, safety study of QR-333 for the treatment of symptomatic diabetic peripheral neuropathy. A preliminary report.一项关于QR-333治疗症状性糖尿病周围神经病变的多中心、双盲安全性研究。初步报告。
J Diabetes Complications. 2005 Sep-Oct;19(5):247-53. doi: 10.1016/j.jdiacomp.2005.05.011.
7
Comparison of nonmydriatic digital retinal imaging versus dilated ophthalmic examination for nondiabetic eye disease in persons with diabetes.非散瞳数字视网膜成像与散瞳眼科检查在糖尿病患者非糖尿病性眼病中的比较
Ophthalmology. 2006 May;113(5):833-40. doi: 10.1016/j.ophtha.2005.12.025.
8
Monoscopic versus stereoscopic retinal photography for grading diabetic retinopathy severity.单目与立体视网膜摄影在糖尿病视网膜病变严重程度分级中的比较。
Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3184-92. doi: 10.1167/iovs.09-4886. Epub 2010 Jan 6.
9
Sensitivity and specificity of digital retinal images in grading diabetic retinopathy.数字视网膜图像在糖尿病视网膜病变分级中的敏感性和特异性。
Acta Ophthalmol Scand. 2004 Apr;82(2):126-30. doi: 10.1111/j.1600-0420.2004.00240.x.
10
Diabetic retinopathy. Screening and prevention of blindness. A doctoral thesis.糖尿病性视网膜病变。失明的筛查与预防。博士论文。
Acta Ophthalmol Scand Suppl. 1997(223):1-76.

引用本文的文献

1
Aldose reductase, ocular diabetic complications and the development of topical Kinostat(®).醛糖还原酶、眼部糖尿病并发症与局部 Kinostat(®)的研发。
Prog Retin Eye Res. 2016 Sep;54:1-29. doi: 10.1016/j.preteyeres.2016.04.006. Epub 2016 Apr 19.

本文引用的文献

1
Effect of aldose reductase inhibitor (tolrestat) on urinary albumin excretion rate and glomerular filtration rate in IDDM subjects with nephropathy.醛糖还原酶抑制剂（托瑞司他）对患有肾病的胰岛素依赖型糖尿病（IDDM）患者尿白蛋白排泄率和肾小球滤过率的影响。
Diabetes Care. 1993 May;16(5):789-95. doi: 10.2337/diacare.16.5.789.
2
Tolrestat for mild diabetic neuropathy. A 52-week, randomized, placebo-controlled trial.托瑞司他治疗轻度糖尿病性神经病变。一项为期52周的随机安慰剂对照试验。
Ann Intern Med. 1993 Jan 1;118(1):7-11. doi: 10.7326/0003-4819-118-1-199301010-00002.
3
Lessons from the Diabetes Control and Complications Trial.糖尿病控制与并发症试验的经验教训。
Diabetes. 1993 Nov;42(11):1549-54. doi: 10.2337/diab.42.11.1549.
4
The aldose reductase controversy.
Diabetes. 1994 Feb;43(2):169-72. doi: 10.2337/diab.43.2.169.
5
The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus.长期强化胰岛素治疗对糖尿病微血管并发症发生发展的影响。
N Engl J Med. 1993 Jul 29;329(5):304-9. doi: 10.1056/NEJM199307293290502.
6
Preventive eye care in people with diabetes is cost-saving to the federal government. Implications for health-care reform.糖尿病患者的预防性眼部护理对联邦政府而言可节省成本。对医疗改革的启示。
Diabetes Care. 1994 Aug;17(8):909-17. doi: 10.2337/diacare.17.8.909.
7
A quantitative system to evaluate diabetic retinopathy from fundus photographs.一种用于从眼底照片评估糖尿病视网膜病变的定量系统。
Invest Ophthalmol Vis Sci. 1995 Jan;36(1):174-81.
8
Prevention of basement membrane thickening in retinal capillaries by a novel inhibitor of aldose reductase, tolrestat.新型醛糖还原酶抑制剂托瑞司他对视网膜毛细血管基底膜增厚的预防作用
Diabetes. 1986 Mar;35(3):295-9. doi: 10.2337/diab.35.3.295.
9
Diabetic retinopathy. A synthesis of perspectives.糖尿病视网膜病变。多视角综述。
N Engl J Med. 1990 Apr 5;322(14):978-83. doi: 10.1056/NEJM199004053221406.
10
A multicentre trial of the aldose-reductase inhibitor, tolrestat, in patients with symptomatic diabetic neuropathy.一项关于醛糖还原酶抑制剂托瑞司他治疗有症状糖尿病神经病变患者的多中心试验。
Diabetologia. 1990 Jul;33(7):431-7. doi: 10.1007/BF00404095.

用于评估接受阿地酶治疗的糖尿病视网膜病变患者的范德比尔特分类系统。

The Vanderbilt Classification System in the evaluation of diabetic retinopathy patients treated with Alredase.

作者信息

Feman S S, Leonard-Martin T C, Redman J R

机构信息

Department of Ophthalmology and Visual Sciences (Fundus Photo Reading Center), School of Medicine, Vanderbilt University, Nashville, Tennessee, USA.

出版信息

Trans Am Ophthalmol Soc. 1996;94:433-47; discussion 447-50.

PMID:8981708
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1312107/
Abstract

BACKGROUND

The Vanderbilt Classification System is a quantitative method of measuring features detected in diabetic retinopathy photographs. It does not require comparisons to preexisting standard photographs. This is the first report of the application of this system to a large-scale, multiple-medical-center drug trial.

METHODS

This was a prospective, randomized, double-masked, placebo-controlled study that involved 74 medical centers. There were 3,679 out-patients followed for more that 4 years, with some observed for over 9 years. The Vanderbilt Classification System generated patient data for the Early Treatment Diabetic Retinopathy Study (ETDRS) and the Diabetes Control and Complication Trial (DCCT) scales. The deterioration rate was one variable used to assess drug effect. A comprehensive Quality Assurance Program evaluated intergrader and intragrader reliability.

RESULTS

Target values for reliability and reproducibility were met or exceeded on all measures of agreement between photo readers and over time. Kappa statistics were 0.610 or greater, with most weighted kappa values greater than 0.810. This represents "almost perfect agreement" and compares favorably with previous reports from the ETDRS and DCCT.

CONCLUSION

Diabetic retinopathy can be evaluated in a reliable and reproducible manner with the VCS. The VCS is unique in that it produces a quantitative analysis of retinal lesions. Subtle variations that might be influenced by systemic medications can be measured accurately with this technique.

摘要

背景

范德比尔特分类系统是一种用于测量糖尿病视网膜病变照片中所检测特征的定量方法。它不需要与预先存在的标准照片进行比较。这是该系统应用于大规模、多医疗中心药物试验的首份报告。

方法

这是一项前瞻性、随机、双盲、安慰剂对照研究，涉及74个医疗中心。有3679名门诊患者随访超过4年，部分患者观察超过9年。范德比尔特分类系统生成了糖尿病视网膜病变早期治疗研究（ETDRS）和糖尿病控制与并发症试验（DCCT）量表的患者数据。恶化率是用于评估药物效果的一个变量。一个全面的质量保证计划评估了分级者之间以及分级者内部的可靠性。

结果

在照片读取者之间以及随着时间推移的所有一致性测量中，可靠性和可重复性的目标值均达到或超过。kappa统计值为0.610或更高，大多数加权kappa值大于0.810。这代表“几乎完全一致”，与ETDRS和DCCT先前的报告相比具有优势。

结论

使用VCS可以以可靠且可重复的方式评估糖尿病视网膜病变。VCS的独特之处在于它能对视网膜病变进行定量分析。可以用这种技术准确测量可能受全身用药影响的细微变化。