Tanzer M, Harvey E, Kay A, Morton P, Bobyn J D
Jo Miller Orthopaedic Research Laboratory, Montreal General Hospital, Quebec, Canada.
J Orthop Res. 1996 Nov;14(6):901-6. doi: 10.1002/jor.1100140609.
Noninvasive low intensity ultrasound has been shown to be an effective means of accelerating bone fracture healing in both animal and clinical studies. An in vivo canine study was designed to determine if noninvasive low intensity ultrasound could influence the rate and extent of bone growth into porous-coated implants. Twenty-two pairs of fully porous transcortical implants were inserted bilaterally into the femora of 12 dogs. In each dog, one femur served as a control and the other was subjected to daily ultrasound stimulation for 2, 3, or 4 weeks. Overall, the ultrasound-stimulated implants demonstrated an 18% increase in bone ingrowth compared with their contralateral controls (p = 0.02). Noninvasive low intensity ultrasound had its greatest effect in the first 2-3 weeks of stimulation. At 2 and 3 weeks, the ultrasound-stimulated implants showed 21 and 16% more ingrowth than their respective contralateral controls. Because noninvasive low intensity ultrasound had a positive effect on bone ingrowth in this experimental investigation, further research is suggested to assess the clinical potential for application to noncemented porous-coated total joint replacements.
在动物和临床研究中，无创低强度超声已被证明是加速骨折愈合的有效手段。一项体内犬类研究旨在确定无创低强度超声是否会影响多孔涂层植入物的骨生长速率和程度。将22对全多孔经皮质植入物双侧植入12只犬的股骨中。在每只犬中，一侧股骨作为对照，另一侧每天接受2、3或4周的超声刺激。总体而言，与对侧对照相比，超声刺激植入物的骨长入增加了18%（p = 0.02）。无创低强度超声在刺激的前2至3周效果最为显著。在第2周和第3周时，超声刺激植入物的长入分别比各自的对侧对照多21%和16%。由于在本实验研究中无创低强度超声对骨长入有积极影响，因此建议进一步研究以评估其应用于非骨水泥多孔涂层全关节置换术的临床潜力。
