Studies on the effect of leukocyte and erythrocyte extracts on the hemopoetic regeneration of sublethally X-irradiated mice.

The cell extracts prepared from leucocytes and erythrocytes of normal rats were applied to C57B1 mice exposed to 300 Rad in 5 injections of 0.5 ml each, during the period of 50-80 hours after irradiation. Significant inhibition in the proliferative compartments of both granulocytic and erythrocytic cells were found in mice submitted to the corresponding cell extract. Our results indicate that cell extracts tested in an animal system demonstrated the same type of inhibitory action as previously reported for the bone marrow cells cultivated in vitro.