Yi H, Nakashima I, Isobe K
Department of Immunology, Nagoya University School of Medicine, Japan.
Am J Chin Med. 1996;24(3-4):271-8. doi: 10.1142/S0192415X96000335.
We studied the actions of glycyrrhizin on nitric oxide production from macrophages and a macrophage cell line RAW264-7. Although glycyrrhizin did not induce nitric oxide from resting macrophages, it enhanced the production of nitric oxide from IFN-gamma activated-macrophages or RAW cells. Glycyrrhizin also enhanced the production of nitric oxide from macrophages stimulated with the supernatant of con A-activated spleen cells. Further, glycyrrhizin enhanced tumor cell killing by macrophages activated with IFN-gamma. This tumor cell killing was mainly by nitric oxide.
我们研究了甘草酸对巨噬细胞及巨噬细胞系RAW264 - 7产生一氧化氮的作用。尽管甘草酸不会诱导静息巨噬细胞产生一氧化氮，但它能增强经γ-干扰素激活的巨噬细胞或RAW细胞产生一氧化氮的能力。甘草酸还能增强经刀豆蛋白A激活的脾细胞上清液刺激的巨噬细胞产生一氧化氮的能力。此外，甘草酸能增强经γ-干扰素激活的巨噬细胞对肿瘤细胞的杀伤作用。这种对肿瘤细胞的杀伤主要是通过一氧化氮实现的。
