Luxemburger C, Price R N, Nosten F, Ter Kuile F O, Chongsuphajaisiddhi T, White N J
Shoklo Malaria Research Unit, Mae Sod, Thailand.
Ann Trop Paediatr. 1996 Dec;16(4):281-6. doi: 10.1080/02724936.1996.11747839.
In an area where multi-drug resistance in Plasmodium falciparum is a particular problem, more than 500 children under 5 years of age weighing > 5 kg were treated with mefloquine, either alone or combined with an artemisinin derivative, and followed up for a minimum of 28 days. The principal adverse effect was vomiting and this was associated with reduced efficacy of treatment (even when treatment was repeated). Later adverse effects occurred less frequently than in adults. There was no serious toxicity and, in particular, there were no neuropsychiatric side-effects. The high dose of mefloquine (25 mg/kg) required in this area is well tolerated by young children. It should be given in a divided dose of 15 mg/kg initially, followed by 10 mg/kg > or = 12 hours later.
在一个恶性疟原虫多重耐药问题尤为突出的地区，500多名体重超过5千克的5岁以下儿童接受了甲氟喹治疗，治疗方式为单独使用甲氟喹或与青蒿素衍生物联合使用，并进行了至少28天的随访。主要不良反应是呕吐，且这与治疗效果降低有关（即使重复治疗时也是如此）。后期不良反应的发生频率低于成人。未出现严重毒性，尤其是未出现神经精神方面的副作用。该地区所需的高剂量甲氟喹（25毫克/千克）幼儿耐受性良好。应先给予15毫克/千克的分次剂量，12小时及以上后再给予10毫克/千克。
