Ishii K, Kumashiro R, Koga Y, Tanikawa K, Furudera S, Mitsuoka M, Sakamoto T, Kaku N
Second Department of Internal Medicine, Kurume University School of Medicine, Japan.
Alcohol Clin Exp Res. 1996 Dec;20(9 Suppl):387A-390A.
We have experienced two patients with alcoholic lactic acidosis complicated with liver disease and diabetes mellitus who were successfully treated. They developed hypoglycemia, dehydration, lactic acidosis, and renal failure after drinking a large volume of alcohol without eating for 1 week before onset. Acidosis was thought to be directly related to excessive alcoholic intake, because it was no associated with severe liver failure and rhabdomyolysis. During monitoring of respiratory and circulatory functions, a rapid infusion of fluids adjusting to water and electrolyte imbalance was performed. A mixture of physiological saline and 5% glucose solution was thought to be effective in these cases. Patients recovered from renal failure and lactic acidosis without hemodialysis. Our experience will hopefully provide a key to successful treatment of fatal alcoholic lactic acidosis.
