蛋白质酪氨酸磷酸酶的结构与功能。
Structure and function of the protein tyrosine phosphatases.
作者信息
Fauman E B, Saper M A
机构信息
Biophysics Research Division, University of Michigan, Ann Arbor 48109-1055, USA.
出版信息
Trends Biochem Sci. 1996 Nov;21(11):413-7. doi: 10.1016/s0968-0004(96)10059-1.
PMID:8987394
Abstract
The tyrosine and dual-specificity phosphatases are involved in signaling, cell growth and differentiation, and the cell cycle. The enzymes share a common catalytic mechanism mediated by an active site cysteine, arginine and aspartic acid. Supplementary domains assist in targeting and substrate specificity.
摘要
酪氨酸磷酸酶和双特异性磷酸酶参与信号传导、细胞生长与分化以及细胞周期。这些酶具有由活性位点半胱氨酸、精氨酸和天冬氨酸介导的共同催化机制。辅助结构域有助于靶向作用和底物特异性。
Zotero 插件