Ruiz-Echevarria M J, Czaplinski K, Peltz S W
Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854, USA.
Trends Biochem Sci. 1996 Nov;21(11):433-8. doi: 10.1016/s0968-0004(96)10055-4.
Messenger RNA (mRNA) degradation is a process that plays an important role in the regulation of gene expression and can be linked to translation. Study of the nonsense-mediated mRNA decay pathway has greatly aided our understanding of the link between these processes. Evidence indicates that this pathway regulates the abundance of both aberrant and wild-type transcripts. Factors involved in this pathway have been identified and recent results indicate that they might also be involved in modulating translation. Here, we discuss the mechanism of nonsense-mediated mRNA decay in the yeast Saccharomyces cerevisiae and the potential role that this pathway can have on the regulation of gene expression.
信使核糖核酸（mRNA）降解是一个在基因表达调控中发挥重要作用且与翻译相关的过程。对无义介导的mRNA衰变途径的研究极大地帮助了我们对这些过程之间联系的理解。有证据表明，该途径调控异常转录本和野生型转录本的丰度。参与此途径的因子已被确定，最近的结果表明它们可能也参与调节翻译。在这里，我们讨论酿酒酵母中无义介导的mRNA衰变机制以及该途径在基因表达调控中可能发挥的潜在作用。
