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生物信息学——一种新型多学科工具的原理与潜力

Bioinformatics--principles and potential of a new multidisciplinary tool.

作者信息

Benton D

机构信息

National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892-6050, USA. benton@extra,nchgr.nih.gov

出版信息

Trends Biotechnol. 1996 Aug;14(8):261-72. doi: 10.1016/0167-7799(96)10037-8.

Abstract

The materials of bioinformatics are biological data, and its methods are derived from a wide variety of computational techniques. Recent years have seen an explosive growth in biological data, and the development of novel computational methods. These methods have become essential to research progress in structural biology, genomics, structure-based drug design and molecular evolution. The development and maintenance of a robust infrastructure of biological data is of equal importance if biotechnology is to take maximum advantage of research advances in a wide variety of fields. While bioinformatics has already made important contributions, it faces significant challenges as it matures.

摘要

生物信息学的材料是生物数据,其方法源自各种各样的计算技术。近年来,生物数据呈爆炸式增长,新的计算方法也不断涌现。这些方法对于结构生物学、基因组学、基于结构的药物设计和分子进化等领域的研究进展至关重要。如果生物技术要充分利用各个领域的研究进展,那么构建和维护强大的生物数据基础设施同样重要。虽然生物信息学已经做出了重要贡献,但随着其不断成熟,也面临着重大挑战。

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