Sugiyama T, Utsumi T, Azuma I, Fujii H
Department of Ophthalmology, Osaka Medical College, Japan.
Jpn J Ophthalmol. 1996;40(3):339-43.
Microcirculation in the optic nerve head (ONH) in the ocular fundus was measured noninvasively using the recently developed laser speckle circulation analyzer. Results were compared with capillary blood flow (CBF) measurements made by the hydrogen clearance method. The ONH blood flow of six normal rabbits was measured simultaneously by both methods. Inhalation of 10% carbon dioxide (CO2) increased the CBF by 22% (hydrogen clearance method). Intravenous injection of endothelin-1 (ET-1) (10(-10) mol/kg) decreased the CBF by 19%. Significant correlations were found between the NB (normalized blur) value by the laser speckle method and CBF (r = 0.38, P < 0.05, n = 30) and also between the relative change of NB and CBF (r = 0.92, P < 0.01, n = 30) in the ONH. This indicates that evaluation of the NB change in the ONH is as accurate with the laser speckle method as with the hydrogen clearance method, giving a basis for the clinical application of the laser speckle method of measuring ONH circulation.
使用最近开发的激光散斑循环分析仪对眼底视神经乳头（ONH）的微循环进行了无创测量。将结果与通过氢清除法进行的毛细血管血流量（CBF）测量结果进行比较。通过两种方法同时测量了六只正常兔子的ONH血流量。吸入10%二氧化碳（CO2）使CBF增加了22%（氢清除法）。静脉注射内皮素-1（ET-1）（10^(-10) mol/kg）使CBF降低了19%。在ONH中，激光散斑法的NB（归一化模糊）值与CBF之间存在显著相关性（r = 0.38，P < 0.05，n = 30），并且NB的相对变化与CBF之间也存在显著相关性（r = 0.92，P < 0.01，n = 30）。这表明，在ONH中，激光散斑法评估NB变化与氢清除法一样准确，为激光散斑法测量ONH循环的临床应用提供了依据。
