Bonithon-Kopp C, Coudray C, Berr C, Touboul P J, Fève J M, Favier A, Ducimetière P
INSERM U258, Paris, France.
Am J Clin Nutr. 1997 Jan;65(1):121-7. doi: 10.1093/ajcn/65.1.121.
There are few epidemiologic studies of the effects of lipid peroxidation and antioxidant status on atherosclerosis. The relation of lipid peroxidation evaluated by thiobarbituric acid-reactive substances (TBARS) and biological markers of antioxidant status to ultrasonographically assessed carotid atherosclerosis was examined from baseline data of a longitudinal study on cognitive and vascular aging (Etude sur le Vieillisement Artériel, the EVA Study). The study sample was composed of 1187 mean and women aged 59-71 y without any history of coronary artery disease or stroke. Ultrasound examination included measurements of intima-media thickness (IMT) on the common carotid arteries (CCAs) and at the site of plaques. After adjustment for conventional cardiovascular risk factors, erythrocyte vitamin E was significantly and negatively associated with CCA-IMT in both men and women whereas plasma selenium and carotenoids were not. No association was found between TBARS and CCA-IMT in either sex. However, TBARS were significantly higher in men with carotid plaques than in those without. This association was strengthened in men with concentrations of erythrocyte vitamin E, plasma selenium, and carotenoids below the lowest quartile. Our findings give some epidemiologic support to the hypothesis that lipid peroxidation and low antioxidant status are involved in the early phases of atherosclerosis.
关于脂质过氧化和抗氧化状态对动脉粥样硬化影响的流行病学研究较少。我们从一项关于认知和血管老化的纵向研究（动脉老化研究，即EVA研究）的基线数据中，考察了用硫代巴比妥酸反应性物质（TBARS）评估的脂质过氧化以及抗氧化状态的生物学标志物与超声评估的颈动脉粥样硬化之间的关系。研究样本由1187名年龄在59 - 71岁之间、无任何冠状动脉疾病或中风病史的男性和女性组成。超声检查包括测量颈总动脉（CCA）和斑块部位的内膜中层厚度（IMT）。在对传统心血管危险因素进行校正后，红细胞维生素E在男性和女性中均与CCA - IMT显著负相关，而血浆硒和类胡萝卜素则无此关联。在任何性别中，均未发现TBARS与CCA - IMT之间存在关联。然而，有颈动脉斑块的男性的TBARS显著高于无斑块者。在红细胞维生素E、血浆硒和类胡萝卜素浓度低于最低四分位数的男性中，这种关联更为明显。我们的研究结果为脂质过氧化和低抗氧化状态参与动脉粥样硬化早期阶段这一假说提供了一些流行病学支持。
