Tahani H, Samia M, Rizk S, Habib Y A, Tallaat M
Z Ernahrungswiss. 1977 Jun;16(2):120-7. doi: 10.1007/BF02021488.
A comparison of serum protein fractions (electrophoretic separation) between control and mild alloxan-diabetic rats examined 10 days after alloxan indicates a decrease in total protein, a decrease in percentage albumin accompanied by a decrease in A/G ratio. In severe diabetic rats examined 48 hours after the administration of alloxan, there were no changes in total protein or in serum-protein fractions. The changes in the serum protein and serum albumin in mild diabetic cases are not the result of the degree of diabetes only. But they are rather explained by the longer time interval of the uncontrolled diabetic state. ATP administered to mild diabetic rats producing the following changes: two injections of 5 mg per rat exhibit a lowering effect on the blood glucose, with a decrease in liver fat. ATP resulted also in a significant increase in serum albumin and a decrease in beta-globulin with a consequent increase in the A/G ratio. Comparison of the different protein fractions of male and female control rats did not show any significant difference. ATP administered to control animals did not alter the normal electrophoretic pattern.
对用四氧嘧啶处理10天后的对照大鼠和轻度四氧嘧啶糖尿病大鼠的血清蛋白组分（电泳分离）进行比较，结果显示总蛋白减少，白蛋白百分比降低，同时A/G比值下降。在用四氧嘧啶处理48小时后的重度糖尿病大鼠中，总蛋白或血清蛋白组分没有变化。轻度糖尿病病例中血清蛋白和血清白蛋白的变化并非仅由糖尿病程度所致。相反，它们更可能是由未控制的糖尿病状态持续时间较长所解释。给轻度糖尿病大鼠注射ATP会产生以下变化：每只大鼠注射两次5毫克ATP对血糖有降低作用，肝脏脂肪减少。ATP还导致血清白蛋白显著增加，β球蛋白减少，从而使A/G比值升高。对雄性和雌性对照大鼠的不同蛋白组分进行比较未显示出任何显著差异。给对照动物注射ATP未改变正常的电泳图谱。
