Akasaka T, Kon S, Mihm M C
Department of Dermatology, Iwate Medical University, School of Medicine, Morioka, Japan.
J Dermatol. 1996 Nov;23(11):821-4. doi: 10.1111/j.1346-8138.1996.tb02706.x.
We report a 22-year-old Japanese woman with multiple basaloid cell hamartoma with alopecia and autoimmune disease (systemic lupus erythematosus). She presented with infiltrated large annular, brown-violet, erythematous plaques with atrophic areas in the center on her right cheek, left abdomen and left knee. She also had progressive multiple follicular keratotic papules on her scalp, face, neck, and both axilla and hair loss from her scalp, eyebrow, and axilla. Serologically, rheumatoid factor (+ + +), rheumatoid arthritis hemagglutination test (x1280), and anti-nuclear antigen (x160) were positive. Histological findings of the annular lesion showed liquefaction degeneration of basal cells, lymphocytic infiltration around hair follicles and capillaries, and panniculitis with lymphoid cell infiltration, which was diagnosed as lupus erythematosus profundus. The histological findings of multiple follicular papular lesions of the scalp and neck showed aggregations of basaloid cells, partially with hair-bulb-like structures, which was diagnosed as trichoepithelioma. Taken together, the histogenesis of multiple basaloid cell hamartoma is thought to share the same basis with autoimmune disease.
我们报告了一名22岁的日本女性，患有多发性基底样细胞错构瘤，并伴有脱发和自身免疫性疾病（系统性红斑狼疮）。她的右脸颊、左腹部和左膝出现浸润性大的环状、棕紫色红斑斑块，中央有萎缩区域。她的头皮、面部、颈部以及双侧腋窝还出现进行性多发性毛囊角化性丘疹，同时伴有头皮、眉毛和腋窝脱发。血清学检查显示，类风湿因子（+++）、类风湿关节炎血凝试验（x1280）和抗核抗原（x160）呈阳性。环状皮损的组织学表现为基底细胞液化变性、毛囊和毛细血管周围淋巴细胞浸润以及伴有淋巴细胞浸润的脂膜炎，诊断为深部红斑狼疮。头皮和颈部多发性毛囊丘疹皮损的组织学表现为基底样细胞聚集，部分伴有毛球样结构，诊断为毛发上皮瘤。综上所述，多发性基底样细胞错构瘤的组织发生被认为与自身免疫性疾病有相同的基础。
