Hopp D C, Zeng L, Gu Z, McLaughlin J L
Department of Medicinal Chemistry and Pharmacognosy, Purdue University, West Lafayette, Indiana 47907-1333, USA.
J Nat Prod. 1996 Feb;59(2):97-9. doi: 10.1021/np960124i.
The bark extracts of Annona squamosa yielded a new bioactive acetogenin, squamotacin (1), and the known compound, molvizarin (2), which is new to this species. Compound 1 is identical to the potent acetogenin, bullatacin (3), except that the adjacent bistetrahydrofuran (THF) rings and their flanking hydroxyls are shifted two carbons toward the gamma-lactone ring. Compound 1 showed cytotoxic selectively for the human prostate tumor cell line (PC-3), with a potency of over 100 million times that of Adriamycin.
番荔枝的树皮提取物产生了一种新的生物活性产乙酸素——鳞甲番荔枝素（1），以及一种已知化合物——莫利扎林（2），该化合物在该物种中是首次发现。化合物1与强效产乙酸素布拉他辛（3）相同，只是相邻的双四氢呋喃（THF）环及其侧翼羟基向γ-内酯环方向移动了两个碳原子。化合物1对人前列腺肿瘤细胞系（PC-3）表现出细胞毒性选择性，其效力比阿霉素高1亿倍以上。
