Kuliszkiewicz-Janus M, Baczyński S
Department of Haematology, Wrocław University of Medicine, Poland.
Magn Reson Med. 1996 Apr;35(4):449-56. doi: 10.1002/mrm.1910350402.
31P spectra were obtained from 22 healthy volunteers and 35 patients with malignant lymphomas. Sera from patients were collected at the time of diagnosis and at several time-points during therapy. Long-term follow-up studies showed a good correlation between the 31P NMR spectra of sera and the clinically evident response of the disease to the chemotherapy. During therapy leading to remission resonance from phospholipids increased progressively resulting in spectra similar to those seen in normal sera. By contrast, in patients who did not respond to therapy the intensities of the phospholipid peaks remained relatively low or became progressively reduced as the disease progressed. To understand the source of the spectral differences, we also examined the concentrations of high-density lipoprotein, low-density lipoprotein, cholesterol, and triglycerides. In individuals responding to the treatment, both high-density lipoprotein and cholesterol increased to the point where they were statistically equivalent to those from healthy volunteers.
对22名健康志愿者和35名恶性淋巴瘤患者进行了磷-31光谱分析。在诊断时以及治疗期间的几个时间点采集患者的血清。长期随访研究表明，血清的磷-31核磁共振光谱与疾病对化疗的临床明显反应之间存在良好的相关性。在导致缓解的治疗过程中，磷脂的共振逐渐增加，产生的光谱类似于正常血清中的光谱。相比之下，在对治疗无反应的患者中，随着疾病进展，磷脂峰的强度保持相对较低或逐渐降低。为了了解光谱差异的来源，我们还检测了高密度脂蛋白、低密度脂蛋白、胆固醇和甘油三酯的浓度。在对治疗有反应的个体中，高密度脂蛋白和胆固醇均增加到在统计学上与健康志愿者的水平相当的程度。
