Logan A C, Khan K N
Searle R&D, Skokie, Illinois 60077, USA.
Toxicol Pathol. 1996 Nov-Dec;24(6):707-9. doi: 10.1177/019262339602400605.
Two sexually mature marmosets (Callithrix jacchus) showing clinical signs similar to those seen in wasting marmoset syndrome (weight loss, decreased muscle mass, and alopecia) were evaluated for clinical and anatomic pathologic changes. The most prominent clinical pathologic alterations included macrocytic normochromic anemia, hypoproteinemia, hypoalbuminemia, elevated serum aspartate aminotransferase and alkaline phosphatase levels, and previously unreported changes of thrombocytosis. The principal gross and histopathologic finding was chronic colitis, which appeared to be the most important contributing factor to the development of wasting syndrome in these marmosets.
对两只性成熟的狨猴（普通狨猴）进行了临床和解剖病理学变化评估，这两只狨猴表现出与消瘦狨猴综合征（体重减轻、肌肉量减少和脱发）相似的临床症状。最显著的临床病理改变包括大细胞正色素性贫血、低蛋白血症、低白蛋白血症、血清天冬氨酸转氨酶和碱性磷酸酶水平升高，以及此前未报告的血小板增多症变化。主要的大体和组织病理学发现是慢性结肠炎，这似乎是这些狨猴消瘦综合征发展的最重要促成因素。
