Stonestreet B S, Patlak C S, Pettigrew K D, Reilly C B, Cserr H F
Department of Pediatrics, Brown University School of Medicine, Providence, Rhode Island, USA.
Am J Physiol. 1996 Dec;271(6 Pt 2):R1594-601. doi: 10.1152/ajpregu.1996.271.6.R1594.
The ontogeny of regional blood-brain barrier function was quantified with the rate constant for influx (Ki) across the blood-brain barrier with the small molecular weight synthetic, inert hydrophilic amino acid alpha-aminoisobutyric acid (AIB) in chronically instrumented early (87 days of gestation, 60% of gestation) and late (137 days of gestation, 90% of gestation) gestation fetal, newborn (3 days of age), older (24 days of age), and adult (3 years of age) sheep. The Ki was significantly (P < 0.05) lower in the brain regions of the adult sheep and in most brain regions of newborn and older lambs compared with fetuses at 60 and 90% of gestation. The Ki exhibited regional brain heterogeneity (P < 0.05) in the five groups. The patterns of regional heterogeneity were accentuated (P < 0.05) in the younger groups. We conclude that ontogenic decreases in blood-brain barrier permeability are observed in ovine fetuses from 60% of gestation to maturity in the adult.
通过用小分子合成惰性亲水性氨基酸α-氨基异丁酸（AIB）测定跨血脑屏障的流入速率常数（Ki），对长期植入仪器的妊娠早期（妊娠87天，妊娠60%）、晚期（妊娠137天，妊娠90%）的胎儿、新生羊（3日龄）、大龄羊（24日龄）和成年羊（3岁）的区域血脑屏障功能的个体发生进行了量化。与妊娠60%和90%时的胎儿相比，成年羊脑区以及新生和大龄羔羊的大多数脑区的Ki显著降低（P<0.05）。在这五组中，Ki表现出脑区异质性（P<0.05）。在较年轻的组中，区域异质性模式更为明显（P<0.05）。我们得出结论，在绵羊胎儿从妊娠60%到成年成熟的过程中，观察到血脑屏障通透性的个体发生性降低。
