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NZB品系小鼠的自发性高血压和高血压性血管疾病。

Spontaneous hypertension and hypertensive vascular disease in the NZB strain of mice.

作者信息

Svendsen U G

出版信息

Acta Pathol Microbiol Scand A. 1977 Jul;85(4):548-54. doi: 10.1111/j.1699-0463.1977.tb03887.x.

DOI:10.1111/j.1699-0463.1977.tb03887.x
PMID:899791
Abstract

NZB nice spontaneously develop a high blood pressure and hypertensive vascular disease in the heart and the kidney. Treatment with cyclophosphamide decreased the level of blood pressure; congenital athymic nude NZB mice failed to develop a high blood pressure. These findings suggest that thymus and the thymus-dependent immune reactions have pathogenic importance for the spontaneous hypertension in these mice.

摘要

新西兰黑鼠（NZB）会自然发生高血压，并在心脏和肾脏出现高血压性血管疾病。用环磷酰胺治疗可降低血压水平；先天性无胸腺裸鼠（NZB）不会发生高血压。这些发现表明，胸腺和胸腺依赖性免疫反应对这些小鼠的自发性高血压具有致病重要性。

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Spontaneous hypertension and hypertensive vascular disease in the NZB strain of mice.NZB品系小鼠的自发性高血压和高血压性血管疾病。
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