Langes K, Beuthien-Baumann B, Lübeck M, Fuchs C, Schneider M A, Volk C, Nienaber C A
Abteilung für Kardiologie, Universitäts-Krankenhaus Eppendorf Hamburg, Deutschland.
Nuklearmedizin. 1996 Dec;35(6):193-7.
In 22 patients with typical chest pain and normal coronary arteries (microvascular angina, syndrome X) 99mTc-MIBI-SPECT was examined in regard to assess impairment of myocardial perfusion reserve.
The study was performed with 99mTc-MIBI-SPECT at rest and under vasodilation with dipyridamole. The findings were compared with a normal database. A normal perfusion reserve was said to be an increase > 20% of the 99mTc-MIBI-activity.
In 2/22 (9%) of the patients the perfusion reserve lay > 20% i.e. 37%. In 91% of the patients a diminution or even decrease of the perfusion was to be seen. From these 9/22 (41%) of the patients showed a diminution of the 99mTc-MIBI-uptake by 6%. 1/22 patients had a decrease of the perfusion under vasodilation with dipyridamole i.e. a lower activity of 99mTc-MIBI by 13%
Vasodilation 99mTc-MIBI-SPECT offers good imaging quality and enables semi-quantitative assessment of myocardial perfusion reserve in patients with microvascular angina.
对22例有典型胸痛且冠状动脉正常（微血管性心绞痛，X综合征）的患者进行99m锝-甲氧基异丁基异腈单光子发射计算机断层扫描（99mTc-MIBI-SPECT），以评估心肌灌注储备受损情况。
采用99mTc-MIBI-SPECT在静息状态及用双嘧达莫进行血管扩张时进行研究。将结果与正常数据库进行比较。正常灌注储备定义为99mTc-MIBI活性增加>20%。
22例患者中有2例（9%）的灌注储备>20%，即37%。91%的患者可见灌注减少甚至降低。其中9例（41%）患者的99mTc-MIBI摄取减少6%。22例患者中有1例在双嘧达莫血管扩张时灌注降低，即99mTc-MIBI活性降低13%。
血管扩张99mTc-MIBI-SPECT提供了良好的成像质量，并能够对微血管性心绞痛患者的心肌灌注储备进行半定量评估。
