Ebermann R, Alth G, Kreitner M, Kubin A
Institute of Chemistry, University of Bodenkultur, Vienna, Austria.
J Photochem Photobiol B. 1996 Nov;36(2):95-7. doi: 10.1016/s1011-1344(96)07353-8.
Chlorophyll and some of its synthetically produced derivatives are important sensitizers in photodynamic cancer therapy. Other natural products from plants with light dependent activity include quinones like hypericin and fagopyrin. These compounds have extended pi-electron systems which upon photoexcitation with visible light are responsible for singlet oxygen production. Other plant constituents which show UV light induced photosensitizing activity are furanocumarins like psoralen and angelicin, aflatoxins and alkaloids, as well as thiophene derivatives, terthienyl and several polyacetylenes. The photodynamic properties of a chelidonium alkaloid derivative and data for its potential clinical applicability are given.
叶绿素及其一些人工合成衍生物是光动力癌症治疗中的重要敏化剂。其他具有光依赖活性的植物天然产物包括金丝桃素和光致敏吡咯素等醌类化合物。这些化合物具有扩展的π电子系统，在可见光激发下会产生单线态氧。其他表现出紫外线诱导光敏活性的植物成分包括补骨脂素和白芷素等呋喃香豆素、黄曲霉毒素和生物碱，以及噻吩衍生物、三联噻吩和几种聚乙炔。本文给出了一种白屈菜生物碱衍生物的光动力性质及其潜在临床适用性的数据。
