Ashammakhi N, Rokkanen P
Department of Orthopaedics and Traumatology, Helsinki University Central Hospital, Finland.
Biomaterials. 1997 Jan;18(1):3-9. doi: 10.1016/s0142-9612(96)00107-x.
Poly(glycolic acid) or polyglycolide (PGA) is a polymer of glycolic acid. Glycolic acid is produced during normal body metabolism and is known as hydroxyacetic acid. Strong implants can be manufactured from this polymer with a self-reinforcing (SR) technique and used in the treatment of fractures and osteotomies. Since 1984, SR-PGA implants have been used routinely in our hospital for internal fixation of bone fractures. These implants were studied extensively in experimental animals and proved biocompatible. In 1.7% of human cases, sinus formation may develop after the use of these implants, which does not disturb healing. Use of these absorbable implants is justified as it obviates the need for a second operation for implant removal and avoids the risks associated with biostable implants.
聚乙醇酸或聚乙交酯（PGA）是乙醇酸的聚合物。乙醇酸在正常身体代谢过程中产生，也被称为羟基乙酸。这种聚合物可通过自增强（SR）技术制成坚固的植入物，用于治疗骨折和截骨术。自1984年以来，SR-PGA植入物一直在我院常规用于骨折的内固定。这些植入物在实验动物中进行了广泛研究，并证明具有生物相容性。在1.7%的人类病例中，使用这些植入物后可能会形成窦道，但这并不影响愈合。使用这些可吸收植入物是合理的，因为它避免了二次手术取出植入物的需要，并避免了与生物稳定性植入物相关的风险。
