新型2-氨基苯并咪唑衍生物的合成与药理性质
Syntheses and pharmacological properties of new 2-aminobenzimidazole derivatives.
作者信息
Nawrocka W
机构信息
Department of Technology of Drugs, Wroclaw University of Medicine, Poland.
出版信息
Boll Chim Farm. 1996 Jan;135(1):18-23.
PMID:9004736
Abstract
The paper reports the structures, syntheses and pharmacological properties of new compounds having a 2-aminobenzimidazole group. They exhibit various activities: histamine H1- and H2-receptors blocking activities, antilipidemic and platelet antiaggregatory, anti-inflammatory and analgesic properties, antimicrobial, fungicidal, parasiticide, antiarrythmic activity and muscle relaxant, comparable to those of drugs used in therapy.
摘要
该论文报道了具有2-氨基苯并咪唑基团的新化合物的结构、合成方法及药理性质。它们具有多种活性：组胺H1和H2受体阻断活性、抗血脂和抗血小板聚集活性、抗炎和镇痛性质、抗菌、杀真菌、抗寄生虫、抗心律失常活性以及肌肉松弛作用，与治疗中使用的药物相当。
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