头孢克洛与头孢氨苄的比较药理学
Comparative pharmacology of cefaclor and cephalexin.
作者信息
Korzeniowski O M, Scheld W M, Sande M A
出版信息
Antimicrob Agents Chemother. 1977 Aug;12(2):157-62. doi: 10.1128/AAC.12.2.157.
Abstract
Two cephalosporin antibiotics, cefaclor and cephalexin, were administered orally to healthy, adult male volunteers for comparison of their pharmacological properties. In doses of 250 mg orally, cefaclor produced a peak serum concentration of 6.01 +/- 0.55 (standard deviation [SD]) mug/ml compared with 9.43 +/- 2.36 mug/ml for cephalexin (P < 0.01). The half-lives were 0.58 +/- 0.07 (SD) h and 0.80 +/- 0.12 (SD) h, and elimination constants were 1.22 +/- 0.15 and 0.88 +/- 0.13 h(-1) for cefaclor and cephalexin, respectively (P < 0.001). Neither drug showed accumulation over the dosing period, and both were well tolerated.
摘要
给健康成年男性志愿者口服两种头孢菌素抗生素——头孢克洛和头孢氨苄，以比较它们的药理特性。口服250毫克剂量时，头孢克洛的血清峰值浓度为6.01±0.55（标准差[SD]）微克/毫升，而头孢氨苄为9.43±2.36微克/毫升（P<0.01）。头孢克洛和头孢氨苄的半衰期分别为0.58±0.07（SD）小时和0.80±0.12（SD）小时，消除常数分别为1.22±0.15和0.88±0.13小时-1（P<0.001）。两种药物在给药期间均未显示出蓄积现象，且耐受性良好。
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本文引用的文献
1
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Appl Microbiol. 1966 Mar;14(2):170-7. doi: 10.1128/am.14.2.170-177.1966.
2
Pharmacokinetics and clinical use of cephalosporin antibiotics.头孢菌素类抗生素的药代动力学及临床应用
J Pharm Sci. 1975 Dec;64(12):1899-926. doi: 10.1002/jps.2600641202.
3
The cephalosporin group of antibiotics.
Adv Pharmacol Chemother. 1975;13:83-172. doi: 10.1016/s1054-3589(08)60231-8.
4
Metabolism of (14C) cefaclor, a cephalosporin antibiotic, in three species of laboratory animals.头孢克洛（一种头孢菌素类抗生素）在三种实验动物体内的代谢情况，其中头孢克洛用（14C）标记 。
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In vitro susceptibility studies with cefaclor and cephalexin.头孢克洛和头孢氨苄的体外药敏试验
Antimicrob Agents Chemother. 1977 Aug;12(2):290-2. doi: 10.1128/AAC.12.2.290.
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