Kurath G, Higman K H, Björklund H V
Northwest Biological Science Center, National Biological Service, Seattle, Washington 98115, USA.
J Gen Virol. 1997 Jan;78 ( Pt 1):113-7. doi: 10.1099/0022-1317-78-1-113.
The fish rhabdovirus infectious haematopoietic necrosis virus (IHNV) contains a non-virion (NV) gene between the glycoprotein (G) and polymerase (L) genes on its RNA genome. The present study investigated three other fish rhabdovirus genomes and found that the NV gene of hirame rhabdovirus is closely related to the NV of IHNV, whereas the viral haemorrhagic septicemia NV gene showed evidence of significant divergence. Most importantly, spring viraemia of carp virus, the only vesiculovirus-like fish rhabdovirus examined, did not have an NV gene at its genomic RNA G-L junction. These results suggest that the presence of an NV gene is characteristic of the unassigned fish rhabdovirus subgroup previously classified as lyssaviruses, and that the NV gene is not essential for replication in fish cells per se, since it is absent in a vesiculovirus-like fish rhabdovirus.
鱼类弹状病毒传染性造血器官坏死病毒（IHNV）在其RNA基因组的糖蛋白（G）基因和聚合酶（L）基因之间含有一个非病毒粒子（NV）基因。本研究调查了其他三种鱼类弹状病毒基因组，发现牙鲆弹状病毒的NV基因与IHNV的NV基因密切相关，而病毒性出血性败血症病毒的NV基因则显示出明显的分化迹象。最重要的是，鲤春病毒血症病毒是唯一被检测的类水疱病毒属鱼类弹状病毒，其基因组RNA的G-L连接处没有NV基因。这些结果表明，NV基因的存在是先前被归类为狂犬病病毒属的未分类鱼类弹状病毒亚组的特征，并且NV基因本身对于在鱼类细胞中的复制并非必不可少，因为在一种类水疱病毒属鱼类弹状病毒中不存在该基因。
