Hann D M, Jacobsen P B, Martin S C, Kronish L E, Azzarello L M, Fields K K
Psychosocial Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa 33612, USA.
Support Care Cancer. 1997 Jan;5(1):44-52. doi: 10.1007/BF01681961.
As more individuals undergo autologous bone marrow transplantation (BMT), there is growing interest in the impact of treatment side effects on quality of life. Fatigue is a potentially disruptive treatment side effect that has not been systematically assessed following BMT. The primary aim of this study was to determine whether the severity of fatigue and its impact on quality of life is significantly greater in women who had undergone BMT for breast cancer than in women of similar age with no history of cancer. Another aim was to identify the medical and psychosocial correlates of fatigue in women who had completed BMT. A group of women treated with autologous BMT for breast cancer (n = 43; mean age = 44; mean time since BMT = 20 months) and a group of women of similar age with no history of cancer (n = 43; mean age = 46) participated in this study. Subjects completed measures of fatigue, anxiety, depression, and sleep habits. Medical data were obtained from computerized patient records. Women who had completed BMT for breast cancer reported significantly more frequent and severe fatigue than women with no cancer history. In addition, fatigue had a significantly greater impact on daily functioning and quality of life in BMT recipients than in women with no cancer history. Fatigue following BMT for breast cancer was related to both medical factors (i.e., time since BMT) and psychosocial factors (i.e., anxiety, depressive symptoms and sleep difficulties). Following BMT for breast cancer, women may experience fatigue that is worse than might "normally" be expected and can interfere with daily functioning and quality of life. Future research should focus on identifying the biological correlates of fatigue, psychological and physiological mechanisms by which fatigue is produced, and interventions to alleviate fatigue.
随着越来越多的人接受自体骨髓移植（BMT），治疗副作用对生活质量的影响越来越受到关注。疲劳是一种潜在的破坏性治疗副作用，在BMT后尚未得到系统评估。本研究的主要目的是确定接受乳腺癌BMT的女性的疲劳严重程度及其对生活质量的影响是否比年龄相仿且无癌症病史的女性显著更大。另一个目的是确定完成BMT的女性疲劳的医学和心理社会相关因素。一组接受乳腺癌自体BMT治疗的女性（n = 43；平均年龄 = 44岁；BMT后平均时间 = 20个月）和一组年龄相仿且无癌症病史的女性（n = 43；平均年龄 = 46岁）参与了本研究。受试者完成了疲劳、焦虑、抑郁和睡眠习惯的测量。医学数据从计算机化的患者记录中获取。完成乳腺癌BMT的女性报告的疲劳比无癌症病史的女性更频繁、更严重。此外，与无癌症病史的女性相比，疲劳对BMT接受者的日常功能和生活质量的影响显著更大。乳腺癌BMT后的疲劳与医学因素（即BMT后的时间）和心理社会因素（即焦虑、抑郁症状和睡眠困难）都有关。乳腺癌BMT后，女性可能会经历比“正常”预期更严重的疲劳，这会干扰日常功能和生活质量。未来的研究应侧重于确定疲劳的生物学相关因素、产生疲劳的心理和生理机制以及减轻疲劳的干预措施。
