Hann D M, Garovoy N, Finkelstein B, Jacobsen P B, Azzarello L M, Fields K K
Behavioral Research Center, American Cancer Society, Atlanta, GA 30329-4251, USA.
J Pain Symptom Manage. 1999 May;17(5):311-9. doi: 10.1016/s0885-3924(99)00007-x.
As more individuals are being treated for cancer with high-dose therapy and autologous stem cell rescue (ASCR), there is growing interest in treatment side effects and their impact on quality of life. The primary aim of this study was to determine if the severity of fatigue and its impact on quality of life is significantly greater in women undergoing ASCR for breast cancer than in women of similar age with no history of cancer. A group of women being treated with ASCR for breast cancer (n = 31) and a group of women of similar age with no history of cancer (n = 49) participated in this study. Patients completed measures of fatigue and psychosocial functioning prior to treatment, midway through treatment, and toward the end of treatment. Healthy comparison subjects completed the same measures three separate times. Breast cancer patients undergoing ASCR reported significantly more frequent fatigue and more severe fatigue than women with no cancer history. In addition, fatigue had a significantly greater impact on daily functioning and quality of life in patients than in women with no cancer history. Fatigue during ASCR for breast cancer was related to both medical factors (i.e., time since transplant) and psychosocial factors. During ASCR for breast cancer, women experience fatigue which is worse than what is "normally" experienced and which interferes with daily functioning and quality of life. Future research should focus on identifying the biological correlates of fatigue, psychological and physiological mechanisms by which fatigue is produced, and interventions to alleviate fatigue.
随着越来越多的个体接受高剂量疗法和自体干细胞救援（ASCR）来治疗癌症，人们对治疗副作用及其对生活质量的影响越来越感兴趣。本研究的主要目的是确定接受乳腺癌ASCR治疗的女性的疲劳严重程度及其对生活质量的影响是否比年龄相仿但无癌症病史的女性显著更大。一组接受乳腺癌ASCR治疗的女性（n = 31）和一组年龄相仿但无癌症病史的女性（n = 49）参与了本研究。患者在治疗前、治疗中期和治疗接近尾声时完成了疲劳和心理社会功能的测量。健康对照受试者分三次完成了相同的测量。接受ASCR治疗的乳腺癌患者报告的疲劳频率明显更高，疲劳程度也更严重。此外，与无癌症病史的女性相比，疲劳对患者日常功能和生活质量的影响明显更大。乳腺癌ASCR期间的疲劳与医学因素（即移植后的时间）和心理社会因素均有关。在乳腺癌ASCR期间，女性经历的疲劳比“正常”经历的更严重，且会干扰日常功能和生活质量。未来的研究应侧重于确定疲劳的生物学关联、产生疲劳的心理和生理机制，以及减轻疲劳的干预措施。
