κ-酪蛋白可抑制培养色素细胞中的黑色素生成。

Kappa-casein suppresses melanogenesis in cultured pigment cells.

作者信息

Nakajima M, Shinoda I, Samejima Y, Miyauchi H, Fukuwatari Y, Hayasawa H

机构信息

Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd., Kanagawa, Japan.

出版信息

Pigment Cell Res. 1996 Oct;9(5):235-9. doi: 10.1111/j.1600-0749.1996.tb00112.x.

DOI:10.1111/j.1600-0749.1996.tb00112.x

PMID:9014209

Abstract

The effects of bovine milk proteins on melanogenesis in B16 cells were examined. Both whey protein isolate and casein exhibited depigmenting properties. Among the major protein components of milk--including beta-lactoglobulin, alpha-lactalbumin, alpha-, beta-, and kappa-casein--only kappa-casein exhibited the depigmenting effect. However, the carboxyl terminal peptide of kappa-casein, glycomacropeptide, did not show this activity. Also, kappa-casein promoted the proliferation of the cells and inhibited the activity of tyrosinase in the cells. These results indicate that kappa-casein acts as a melanogenesis-suppressing modulator.

摘要

研究了牛乳蛋白对B16细胞黑色素生成的影响。乳清分离蛋白和酪蛋白均表现出脱色特性。在牛奶的主要蛋白质成分中——包括β-乳球蛋白、α-乳白蛋白、α-、β-和κ-酪蛋白——只有κ-酪蛋白表现出脱色作用。然而，κ-酪蛋白的羧基末端肽，即糖巨肽，并未表现出这种活性。此外，κ-酪蛋白促进细胞增殖并抑制细胞中酪氨酸酶的活性。这些结果表明，κ-酪蛋白作为一种黑色素生成抑制调节剂发挥作用。