Nakajima M, Shinoda I, Samejima Y, Miyauchi H, Fukuwatari Y, Hayasawa H
Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd., Kanagawa, Japan.
Pigment Cell Res. 1996 Oct;9(5):235-9. doi: 10.1111/j.1600-0749.1996.tb00112.x.
The effects of bovine milk proteins on melanogenesis in B16 cells were examined. Both whey protein isolate and casein exhibited depigmenting properties. Among the major protein components of milk--including beta-lactoglobulin, alpha-lactalbumin, alpha-, beta-, and kappa-casein--only kappa-casein exhibited the depigmenting effect. However, the carboxyl terminal peptide of kappa-casein, glycomacropeptide, did not show this activity. Also, kappa-casein promoted the proliferation of the cells and inhibited the activity of tyrosinase in the cells. These results indicate that kappa-casein acts as a melanogenesis-suppressing modulator.
研究了牛乳蛋白对B16细胞黑色素生成的影响。乳清分离蛋白和酪蛋白均表现出脱色特性。在牛奶的主要蛋白质成分中——包括β-乳球蛋白、α-乳白蛋白、α-、β-和κ-酪蛋白——只有κ-酪蛋白表现出脱色作用。然而，κ-酪蛋白的羧基末端肽，即糖巨肽，并未表现出这种活性。此外，κ-酪蛋白促进细胞增殖并抑制细胞中酪氨酸酶的活性。这些结果表明，κ-酪蛋白作为一种黑色素生成抑制调节剂发挥作用。
