Han Geonhee, Kim Hyosuk, Kim Da Eun, Ahn Yeonjoo, Kim Joongsoo, Jang Ye Ji, Kim Kwangmeyung, Yang Yoosoo, Kim Sun Hwa
KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seoul 02841, Korea.
Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seoul 02792, Korea.
Pharmaceutics. 2022 Jan 27;14(2):307. doi: 10.3390/pharmaceutics14020307.
In this study, we examined the potentially beneficial effects of bovine colostrum-derived exosomes on UV-induced aging and damage in three major resident skin cells including keratinocytes, melanocytes, and fibroblasts. The treatment with colostrum exosomes prevented the UV-induced generation of intracellular reactive oxygen species in epidermal keratinocytes. In UV-stimulated melanocytes, colostrum exosomes could also significantly reduce the production of the protective skin-darkening pigment melanin, which may help to reduce the risk of excessive melanin formation causing skin hyperpigmentation disorders. In the human dermal fibroblasts treated with colostrum exosomes, the expression of matrix metalloproteinases was suppressed, whereas increased cell proliferation was accompanied by enhanced production of collagen, a major extracellular matrix component of skin. Taken together, our findings indicate that bovine colostrum-derived exosomes having excellent structural and functional stability offer great potential as natural therapeutic agents to repair UV-irradiated skin aging and damage.
在本研究中，我们检测了牛初乳来源的外泌体对紫外线诱导的三种主要皮肤驻留细胞（包括角质形成细胞、黑素细胞和成纤维细胞）衰老和损伤的潜在有益作用。用初乳外泌体处理可防止紫外线诱导表皮角质形成细胞内活性氧的产生。在紫外线刺激的黑素细胞中，初乳外泌体还可显著减少保护性皮肤变黑色素黑色素的产生，这可能有助于降低过量黑色素形成导致皮肤色素沉着紊乱的风险。在用初乳外泌体处理的人真皮成纤维细胞中，基质金属蛋白酶的表达受到抑制，而细胞增殖增加伴随着胶原蛋白（皮肤主要细胞外基质成分）产量的增加。综上所述，我们的研究结果表明，具有优异结构和功能稳定性的牛初乳来源的外泌体作为修复紫外线照射引起的皮肤衰老和损伤的天然治疗剂具有巨大潜力。
