基因银行
GenBank.
作者信息
Benson D A, Boguski M S, Lipman D J, Ostell J
机构信息
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.
出版信息
Nucleic Acids Res. 1997 Jan 1;25(1):1-6. doi: 10.1093/nar/25.1.1.
The GenBank sequence database incorporates DNA sequences from all available public sources, primarily through the direct submission of sequence data from authors and from large-scale sequencing projects. Data exchange with the EMBL Data Library and the DNA Data Bank of Japan helps ensure comprehensive coverage. GenBank continues to focus on quality control and annotation while expanding data coverage and retrieval services. An integrated retrieval system, known asEntrez, incorporates data from the major DNA and protein sequence databases, along with genome maps and protein structure information. MEDLINE abstracts from published articles describing the sequences are also included as an additional source of biological annotation. Sequence similarity searching is offered through the BLAST family of programs. All of NCBI's services are offered through the World Wide Web. In addition, there are specialized server/client versions as well as FTP and e-mail server access.
GenBank序列数据库整合了来自所有可用公共来源的DNA序列，主要是通过作者直接提交序列数据以及大规模测序项目来实现。与欧洲分子生物学实验室数据库（EMBL Data Library）和日本DNA数据库（DNA Data Bank of Japan）的数据交换有助于确保全面覆盖。GenBank在扩大数据覆盖范围和检索服务的同时，继续专注于质量控制和注释。一个名为Entrez的综合检索系统整合了来自主要DNA和蛋白质序列数据库的数据，以及基因组图谱和蛋白质结构信息。描述这些序列的已发表文章的MEDLINE摘要也作为生物注释的额外来源被纳入其中。通过BLAST系列程序提供序列相似性搜索。美国国立医学图书馆国家生物技术信息中心（NCBI）的所有服务都通过万维网提供。此外，还有专门的服务器/客户端版本以及FTP和电子邮件服务器访问方式。
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