Calò D, De Pascali A, Sasanelli D, Tanzariello F, Tommaseo Ponzetta M, Saccone C, Attimonelli M
Dipartimento di Biochimica e Biologia Molecolare, Università di Bari, 70125 Bari, Italy.
Nucleic Acids Res. 1997 Jan 1;25(1):200-5. doi: 10.1093/nar/25.1.200.
The present paper describes the structure of MmtDB-a specialized database designed to collect Metazoa mitochondrial DNA variants. Priority in the data collection is given to the Metazoa species for which a large amount of variants is available, as it is the case for human variants. Starting from the sequences available in the Nucleotide Sequence Databases, the redundant sequences are removed and new sequences from other sources are added. Value-added information are associated to each variant sequence, e.g. analysed region, experimental method, tissue and cell lines, population data, sex, age, family code and information about the variation events (nucleotide position, involved gene, restriction site's gain or loss). Cross-references are introduced to the EMBL Data Library, as well as an internal cross-referencing among MmtDB entries according to their tissual, heteroplasmic, familiar and aplotypical correlation. MmtDB can be accessed through the World Wide Web at URL [see text].
本文描述了MmtDB的结构,这是一个专门设计用于收集后生动物线粒体DNA变异的数据库。数据收集优先考虑有大量变异的后生动物物种,就像人类变异的情况一样。从核苷酸序列数据库中可用的序列开始,去除冗余序列并添加来自其他来源的新序列。增值信息与每个变异序列相关联,例如分析区域、实验方法、组织和细胞系、群体数据、性别、年龄、家族代码以及关于变异事件的信息(核苷酸位置、涉及的基因、限制位点的获得或丢失)。引入了到EMBL数据库的交叉引用,以及根据MmtDB条目的组织、异质性、家族性和单倍型相关性在条目之间进行的内部交叉引用。可以通过万维网在URL [见正文] 访问MmtDB。