哺乳动物嗅觉受体基因的进化。
The evolution of mammalian olfactory receptor genes.
作者信息
Issel-Tarver L, Rine J
机构信息
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.
出版信息
Genetics. 1997 Jan;145(1):185-95. doi: 10.1093/genetics/145.1.185.
Abstract
We performed a comparative study of four subfamilies of olfactory receptor genes first identified in the dog to assess changes in the gene family during mammalian evolution, and to begin linking the dog genetic map to that of humans. The human subfamilies were localized to chromosomes 7, 11, and 19. The two subfamilies that were tightly linked in the dog genome were also tightly linked in the human genome. The four subfamilies were compared in human (primate), horse (perissodactyl), and a variety of artiodactyls and carnivores. Some changes in gene number were detected, but overall subfamily size appeared to have been established before the divergence of these mammals 60-100 million years ago.
摘要
我们对最初在狗身上发现的嗅觉受体基因的四个亚家族进行了比较研究，以评估该基因家族在哺乳动物进化过程中的变化，并开始将狗的遗传图谱与人类的遗传图谱联系起来。人类亚家族定位于7号、11号和19号染色体上。在狗基因组中紧密连锁的两个亚家族在人类基因组中也紧密连锁。我们在人类（灵长类）、马（奇蹄目）以及各种偶蹄目动物和食肉动物中对这四个亚家族进行了比较。检测到了基因数量的一些变化，但总体而言，亚家族的大小似乎在6000万至1亿年前这些哺乳动物分化之前就已确定。
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