Kidder L H, Kalasinsky V F, Luke J L, Levin I W, Lewis E N
Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0510, USA.
Nat Med. 1997 Feb;3(2):235-7. doi: 10.1038/nm0297-235.
Between 1 and 2 million women in the United States have silicone breast implants. Complications include capsular contracture and calcification and possibly connective tissue diseases such as scleroderma and rheumatoid arthritis, a subject of some controversy. In order to accurately assess the role of silicone in any histopathologic change, it is necessary to confirm its presence and to identify other foreign materials in the capsular tissue. Although light microscopy is used to visualize regions of tissue containing foreign inclusions, their chemical identity can only be determined using analytical techniques such as infrared or Raman microscopy. However, these conventional microprobe techniques record spectra only at single points and require an a priori knowledge of the locations of the inclusion to be probed. To significantly extend the capabilities of both infrared spectroscopy and optical microscopy, we have developed a new infrared imaging system that completely integrates these two methods. In this manuscript we highlight the ability of the technique to screen rapidly and to determine accurately the presence, size and chemical composition of silicone gel inclusions in human breast tissue.
美国有100万到200万女性植入了硅胶乳房假体。并发症包括包膜挛缩和钙化，还可能引发硬皮病和类风湿性关节炎等结缔组织疾病，这是一个存在一定争议的话题。为了准确评估硅胶在任何组织病理学变化中的作用，有必要确认其存在，并识别包膜组织中的其他异物。虽然光学显微镜用于观察含有外来内含物的组织区域，但它们的化学特性只能使用红外或拉曼显微镜等分析技术来确定。然而，这些传统的微探针技术仅在单点记录光谱，并且需要事先了解要探测的内含物的位置。为了显著扩展红外光谱和光学显微镜的功能，我们开发了一种全新的红外成像系统，该系统将这两种方法完全整合在一起。在本论文中，我们重点介绍了该技术快速筛选并准确确定人类乳腺组织中硅胶凝胶内含物的存在、大小和化学成分的能力。
