低剂量 EPA 和 DHA 对二甲基苯并蒽诱导的大鼠乳腺癌发生的化学预防作用。
Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA.
作者信息
Noguchi M, Minami M, Yagasaki R, Kinoshita K, Earashi M, Kitagawa H, Taniya T, Miyazaki I
机构信息
Operation Center, Kanazawa University Hospital, Takara-machi, Japan.
出版信息
Br J Cancer. 1997;75(3):348-53. doi: 10.1038/bjc.1997.57.
Abstract
We investigated the effects of low-dose eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the incidence and growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in rats fed a high-fat (HF) diet. We also examined the effects of these treatments on the fatty acid composition of tumour and serum. Tumour incidence was significantly decreased by the administration of low-dose EPA and DHA, whereas their inhibitory effects on tumour growth did not reach significance. Serum arachidonic acid (AA) level was decreased by the administration of low-dose EPA and tended to be decreased by the administration of low-dose DHA, whereas tumour AA levels were not changed. The administration of low-dose EPA and DHA may be useful for inhibiting the incidence of breast cancer.
摘要
我们研究了低剂量二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）对高脂（HF）饮食喂养的大鼠中7,12-二甲基苯并（a）蒽（DMBA）诱导的乳腺癌的发生率和生长的影响。我们还研究了这些处理对肿瘤和血清脂肪酸组成的影响。低剂量EPA和DHA的给药显著降低了肿瘤发生率，而它们对肿瘤生长的抑制作用未达到显著水平。低剂量EPA给药降低了血清花生四烯酸（AA）水平，低剂量DHA给药使其有降低趋势，而肿瘤AA水平未改变。低剂量EPA和DHA的给药可能有助于抑制乳腺癌的发生率。
相似文献
1
Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA.低剂量 EPA 和 DHA 对二甲基苯并蒽诱导的大鼠乳腺癌发生的化学预防作用。
Br J Cancer. 1997;75(3):348-53. doi: 10.1038/bjc.1997.57.
2
Effects of low-dose eicosapentaenoic acid, docosahexaenoic acid and dietary fat on the incidence, growth and cell kinetics of mammary carcinomas in rats.低剂量二十碳五烯酸、二十二碳六烯酸及膳食脂肪对大鼠乳腺癌发病率、生长及细胞动力学的影响。
Oncology. 1996 Sep-Oct;53(5):398-405. doi: 10.1159/000227595.
3
Dietary docosahexaenoic acid suppresses N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats more effectively than eicosapentaenoic acid.膳食中的二十二碳六烯酸比二十碳五烯酸更有效地抑制N-甲基-N-亚硝基脲诱导的大鼠乳腺癌发生。
Nutr Cancer. 2003;45(2):211-7. doi: 10.1207/S15327914NC4502_11.
4
Dietary fish oil associated with increased apoptosis and modulated expression of Bax and Bcl-2 during 7,12-dimethylbenz(alpha)anthracene-induced mammary carcinogenesis in rats.在大鼠7,12-二甲基苯并(α)蒽诱导的乳腺癌发生过程中，膳食鱼油与细胞凋亡增加以及Bax和Bcl-2表达的调节有关。
Prostaglandins Leukot Essent Fatty Acids. 2008 Jul-Aug;79(1-2):5-14. doi: 10.1016/j.plefa.2008.05.005. Epub 2008 Jul 9.
5
Black tea and mammary gland carcinogenesis by 7,12-dimethylbenz[a]anthracene in rats fed control or high fat diets.红茶与7,12-二甲基苯并[a]蒽在喂食对照或高脂饮食大鼠中诱发乳腺癌的关系
Carcinogenesis. 1998 Jul;19(7):1269-73. doi: 10.1093/carcin/19.7.1269.
6
Dose response chemopreventive potential of allyl isothiocyanate against 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in female Sprague-Dawley rats.异硫氰酸烯丙酯对7,12-二甲基苯并(a)蒽诱导的雌性斯普拉格-道利大鼠乳腺癌发生的剂量反应化学预防潜力。
Chem Biol Interact. 2015 Apr 25;231:35-43. doi: 10.1016/j.cbi.2015.02.015. Epub 2015 Mar 2.
7
Influence of esculetin on incidence, proliferation, and cell kinetics of mammary carcinomas induced by 7,12-dimethylbenz[a]anthracene in rats on high- and low-fat diets.七叶亭对高脂和低脂饮食大鼠中由7,12-二甲基苯并[a]蒽诱导的乳腺癌的发生率、增殖及细胞动力学的影响。
Jpn J Cancer Res. 1993 Oct;84(10):1010-4. doi: 10.1111/j.1349-7006.1993.tb02793.x.
8
Comparative effects of piroxicam and esculetin on incidence, proliferation, and cell kinetics of mammary carcinomas induced by 7,12-dimethylbenz[a]anthracene in rats on high- and low-fat diets.吡罗昔康和七叶亭对高脂和低脂饮食大鼠经7,12-二甲基苯并[a]蒽诱导的乳腺癌的发病率、增殖及细胞动力学的比较影响。
Oncology. 1994 Sep-Oct;51(5):401-10. doi: 10.1159/000227374.
9
Inhibition of chemically induced mammary carcinogenesis in rats by long-term exposure to butylated hydroxytoluene (BHT): interrelations among BHT concentration, carcinogen dose, and diet.长期接触丁基羟基甲苯（BHT）对化学诱导的大鼠乳腺癌发生的抑制作用：BHT浓度、致癌物剂量和饮食之间的相互关系。
J Natl Cancer Inst. 1986 Apr;76(4):721-30. doi: 10.1093/jnci/76.4.721.
10
Dose-response effects of the COX-2 inhibitor, celecoxib, on the chemoprevention of mammary carcinogenesis.环氧化酶-2（COX-2）抑制剂塞来昔布对乳腺癌化学预防的剂量反应效应。
Anticancer Res. 2001 Sep-Oct;21(5):3425-32.
引用本文的文献
1
Biomimetic Nanomaterials Triggered Ferroptosis for Cancer Theranostics.用于癌症诊疗的仿生纳米材料引发铁死亡
Front Chem. 2021 Nov 16;9:768248. doi: 10.3389/fchem.2021.768248. eCollection 2021.
2
Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer.脂氧合酶催化二十二碳六烯酸衍生的代谢物是有前途的针对乳腺癌的抗肿瘤药物。
Sci Rep. 2021 Jan 11;11(1):410. doi: 10.1038/s41598-020-79716-x.
3
Targeting ferroptosis in breast cancer.针对乳腺癌中的铁死亡
Biomark Res. 2020 Nov 5;8(1):58. doi: 10.1186/s40364-020-00230-3.
4
Carcinogenesis: Failure of resolution of inflammation?致癌作用：炎症反应无法解决？
Pharmacol Ther. 2021 Feb;218:107670. doi: 10.1016/j.pharmthera.2020.107670. Epub 2020 Sep 3.
5
Immune regulation and anti-cancer activity by lipid inflammatory mediators.脂质炎症介质的免疫调节和抗癌活性。
Int Immunopharmacol. 2018 Dec;65:580-592. doi: 10.1016/j.intimp.2018.10.026. Epub 2018 Nov 14.
6
Lipid Inflammatory Mediators in Cancer Progression and Therapy.脂类炎症介质在癌症进展和治疗中的作用。
Adv Exp Med Biol. 2017;1036:145-156. doi: 10.1007/978-3-319-67577-0_10.
7
Docosahexaenoic Acid in Combination with Dietary Energy Restriction for Reducing the Risk of Obesity Related Breast Cancer.二十二碳六烯酸联合饮食能量限制减少肥胖相关乳腺癌的风险。
Int J Mol Sci. 2017 Dec 22;19(1):28. doi: 10.3390/ijms19010028.
8
Alpha-linolenic acid stabilizes HIF-1 α and downregulates FASN to promote mitochondrial apoptosis for mammary gland chemoprevention.α-亚麻酸可稳定缺氧诱导因子-1α并下调脂肪酸合酶，以促进线粒体凋亡从而预防乳腺癌。
Oncotarget. 2017 Jul 25;8(41):70049-70071. doi: 10.18632/oncotarget.19551. eCollection 2017 Sep 19.
9
Oxidized derivative of docosahexaenoic acid preferentially inhibit cell proliferation in triple negative over luminal breast cancer cells.二十二碳六烯酸的氧化衍生物在三阴性乳腺癌细胞中比腔面型乳腺癌细胞更能优先抑制细胞增殖。
In Vitro Cell Dev Biol Anim. 2015 Feb;51(2):121-7. doi: 10.1007/s11626-014-9822-6. Epub 2014 Nov 21.
10
Low-density lipoprotein-mediated delivery of docosahexaenoic acid selectively kills murine liver cancer cells.低密度脂蛋白介导的二十二碳六烯酸递送可选择性杀死小鼠肝癌细胞。
Nanomedicine (Lond). 2014 Jul;9(14):2123-41. doi: 10.2217/nnm.13.187. Epub 2014 Jan 7.
本文引用的文献
1
A simple method for the isolation and purification of total lipides from animal tissues.一种从动物组织中分离和纯化总脂质的简单方法。
J Biol Chem. 1957 May;226(1):497-509.
2
Observations on growth rates of human tumors.关于人类肿瘤生长速率的观察
Am J Roentgenol Radium Ther Nucl Med. 1956 Nov;76(5):988-1000.
3
Epidemiology of Breast Cancer in Japan.日本乳腺癌的流行病学
Breast Cancer. 1995 Apr 30;2(1):1-7. doi: 10.1007/BF02966890.
4
Effects of low-dose eicosapentaenoic acid, docosahexaenoic acid and dietary fat on the incidence, growth and cell kinetics of mammary carcinomas in rats.低剂量二十碳五烯酸、二十二碳六烯酸及膳食脂肪对大鼠乳腺癌发病率、生长及细胞动力学的影响。
Oncology. 1996 Sep-Oct;53(5):398-405. doi: 10.1159/000227595.
5
Effect of varying proportions of dietary menhaden and corn oil on experimental rat mammary tumor promotion.不同比例的鲱鱼油和玉米油饮食对实验大鼠乳腺肿瘤促发的影响。
Lipids. 1993 May;28(5):449-56. doi: 10.1007/BF02535944.
6
Controversial issues of dietary fat and experimental mammary carcinogenesis.膳食脂肪与实验性乳腺癌发生的争议性问题。
Prev Med. 1993 Sep;22(5):728-37. doi: 10.1006/pmed.1993.1067.
7
8
The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma.脂肪酸和类花生酸合成抑制剂在乳腺癌中的作用
Oncology. 1995 Jul-Aug;52(4):265-71. doi: 10.1159/000227471.
9
Influence of diets containing eicosapentaenoic or docosahexaenoic acid on growth and metastasis of breast cancer cells in nude mice.含二十碳五烯酸或二十二碳六烯酸的饮食对裸鼠乳腺癌细胞生长和转移的影响。
J Natl Cancer Inst. 1995 Apr 19;87(8):587-92. doi: 10.1093/jnci/87.8.587.
10
Effects of indomethacin with or without linoleic acid on human breast cancer cells in vitro.吲哚美辛联合或不联合亚油酸对人乳腺癌细胞的体外作用
Prostaglandins Leukot Essent Fatty Acids. 1995 Jun;52(6):381-6. doi: 10.1016/0952-3278(95)90065-9.
Zotero 插件