Knapp D W, Waters D J
Dept of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN 47907-1248, USA.
Mol Med Today. 1997 Jan;3(1):8-11. doi: 10.1016/s1357-4310(96)20031-0.
It has been said that "dog is man's best friend'. Comparative oncologists are demonstrating that pet dogs could hold the keys for advances in cancer treatment in people. Specific types of cancer that arise spontaneously in pet dogs could serve as important models of human cancer, having much greater similarity to their counterparts in humans than many currently used experimentally induced tumor models. In vivo models that are relevant to human cancer are greatly needed, particularly for evaluating new strategies for cancer therapy, such as augmentation of the immune system or blockade of the metastatic cascade. In addition, pet dogs could also be used to identify environmental carcinogens by acting as sentinels of cancer induced by these toxins.
“狗是人类最好的朋友”。比较肿瘤学家正在证明，宠物狗可能是人类癌症治疗取得进展的关键所在。宠物狗自发产生的特定类型癌症可作为人类癌症的重要模型，与人类的同类癌症相比，它们与人类癌症的相似性比许多目前使用的实验诱导肿瘤模型要高得多。非常需要与人类癌症相关的体内模型，特别是用于评估癌症治疗的新策略，如增强免疫系统或阻断转移级联反应。此外，宠物狗还可以作为这些毒素诱发癌症的哨兵，用于识别环境致癌物。
