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抗胆碱酯酶诱导的失忆及其时间特征。

Anticholinesterase-induced amnesia and its temporal aspects.

作者信息

Deutsch J A, Hamburg M D, Dahl H

出版信息

Science. 1966 Jan 14;151(3707):221-3. doi: 10.1126/science.151.3707.221.

DOI:10.1126/science.151.3707.221
PMID:5948540
Abstract

Injection of the anticholinesterase drug diisopropyl fluorophosphate into the hippocampi of rats, 30 minutes after escape learning, produces partial amnesia with full recovery 5 days after injection. No such amnesia is produced if the injection takes place 3 days after learning. However, with injections 5 days after learning there is again an effect, and at 14 days amnesia is complete though no normal forgetting occurs within this period.

摘要

在大鼠逃脱学习30分钟后,向其海马体注射抗胆碱酯酶药物二异丙基氟磷酸酯,会导致部分失忆,注射5天后完全恢复。如果在学习3天后注射,则不会产生这种失忆现象。然而,在学习5天后注射又会产生影响,在14天时失忆完全,但在此期间不会出现正常遗忘的情况。

相似文献

1
Anticholinesterase-induced amnesia and its temporal aspects.抗胆碱酯酶诱导的失忆及其时间特征。
Science. 1966 Jan 14;151(3707):221-3. doi: 10.1126/science.151.3707.221.
2
Amnesia or reversal of forgetting by anticholinesterase, depending simply on time of injection.失忆症或通过抗胆碱酯酶逆转遗忘,这仅仅取决于注射时间。
Science. 1966 Aug 26;153(3739):1017-8. doi: 10.1126/science.153.3739.1017.
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Retrograde amnesia produced by intraperitoneal injection of physostigmine.腹腔注射毒扁豆碱所致逆行性遗忘。
Science. 1967 May 19;156(3777):973-4. doi: 10.1126/science.156.3777.973.
4
Temporal aspects of anticholinergic-and anticholinesterase-induced amnesia for an appetitive habit.抗胆碱能和抗胆碱酯酶诱导的食欲习惯失忆的时间特征。
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Amnesic effects of small bilateral brain puncture in the mouse.小鼠双侧小范围脑穿刺的失忆效应
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6
The influence of ovariectomy on the sex-dependent effects of the anticholinesterase diisopropyl fluorophosphate.卵巢切除术对抗胆碱酯酶药物氟磷酸二异丙酯性别依赖性效应的影响。
Psychopharmacology (Berl). 1981;74(4):391-2. doi: 10.1007/BF00432755.
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The effect of diisopropyl fluorophosphonate on the sensitivity of rats to centrally acting drugs.氟磷酸二异丙酯对大鼠对中枢作用药物敏感性的影响。
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Amnesia induced by scopolamine and its temporal variations.东莨菪碱所致失忆及其时间变化。
Nature. 1967 Oct 7;216(5110):89-90. doi: 10.1038/216089b0.
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Experimental tests of hypotheses about neurochemical mechanisms underlying behavioral tolerance to the anticholinesterase, diisopropyl fluorophosphate.
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A brief temporal gradient of retrograde amnesia independent of situational change.一种与情境变化无关的短暂逆行性遗忘时间梯度。
Science. 1965 Sep 3;149(3688):1116-8. doi: 10.1126/science.149.3688.1116.

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Effects of cigarette smoking on learning and retention.吸烟对学习和记忆的影响。
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