没有证据表明该产品对大鼠肾素 - 血管紧张素原反应有抑制作用。
No evidence for product inhibition of the renin-angiotensinogen reaction in the rat.
作者信息
Hackenthal E, Hackenthal R, Hofbauer K G
出版信息
Circ Res. 1977 Oct;41(4 Suppl 2):49-54. doi: 10.1161/01.res.41.4.49.
PMID:902373
Abstract
The influence of the product of the renin-angiotensinogen reaction, the des-angiotensin I-substrate (des-AI-substrate) on the renin-angiotensinogen reaction has been studied. Des-AI-substrate was prepared from purified rat angiotensinogen by reaction with immobilized renin. The des-AI-substrate had no inhibitory effect on the reaction of partially purified rat renin with rat angiotensinogen at concentrations corresponding to 0.225 or 0.45 micrometer angiotensinogen.
摘要
肾素-血管紧张素原反应产物——去血管紧张素I底物（des-AI-底物）对肾素-血管紧张素原反应的影响已得到研究。通过与固定化肾素反应，从纯化的大鼠血管紧张素原制备了des-AI-底物。在对应于0.225或0.45微摩尔血管紧张素原的浓度下，des-AI-底物对部分纯化的大鼠肾素与大鼠血管紧张素原的反应没有抑制作用。
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