Fang V S, Cho H W, Meltzer H Y
Clin Chem. 1977 Oct;23(10):1898-902.
We have developed a radioimmunoassay technique that is highly specific for measuring the MM isoenzyme of creatine kinase. The specificity of the radioimmunoassay for the BB isoenzyme was poor. In patients with treated Duchenne-type muscular dystrophy or untreated hypothyroidism, the MM isoenzyme, but not the BB isoenzyme value, was consistently above above normal. In the radioimmunoassay for the BB isoenzyme the antisera might cross react with other materials and the inactivated isoenzyme, but not with MM or MB isoenzymes.
我们开发了一种放射免疫测定技术，该技术对测量肌酸激酶的MM同工酶具有高度特异性。该放射免疫测定法对BB同工酶的特异性较差。在接受治疗的杜兴型肌营养不良症患者或未经治疗的甲状腺功能减退症患者中，MM同工酶值始终高于正常水平，而BB同工酶值则不然。在针对BB同工酶的放射免疫测定中，抗血清可能会与其他物质和失活的同工酶发生交叉反应，但不会与MM或MB同工酶发生交叉反应。
