Pindel B, Pluskiewicz W
Katedry i Kliniki Chorób Wewnetrznych i Alergologii Slaskiej AM.
Chir Narzadow Ruchu Ortop Pol. 1996;61(5):487-91.
Bone remodelling is a complex process involving a number of cellular functions directed toward the coordinated resorption and formation of new bone. Bone remodelling is regulated by systemic hormones and by local factors. The local factors are synthetized by skeletal cells and include growth factors and cytokines. The end product of remodeling is the maintenance of a mineralized bone matrix, and the major organic component is the collagen. Local factors play an important role in pathophysiology of osteoporosis as systemic hormones.
骨重塑是一个复杂的过程，涉及许多细胞功能，旨在协调新骨的吸收和形成。骨重塑受全身激素和局部因素调节。局部因素由骨骼细胞合成，包括生长因子和细胞因子。重塑的最终产物是维持矿化的骨基质，主要有机成分是胶原蛋白。局部因素在骨质疏松症的病理生理学中与全身激素一样起着重要作用。
