Tobe H, Muraki Y, Kitamura K, Komiyama O, Sato Y, Sugioka T, Maruyama H B, Matsuda E, Nagai M
Pharma Research and Development Division, Hoechst Japan Limited, Saitama, Japan.
Biosci Biotechnol Biochem. 1997 Jan;61(1):158-9. doi: 10.1271/bbb.61.158.
We searched hop extract for active component(s) that inhibited bone resorption in the pit formation assay, and isolated xanthohumol and humulone as active ingredients. Especially humulone had extraordinarily strong inhibitory activity and the IC50 (concentration of 50% inhibition) value was 5.9 x 10(-9)M.
我们在啤酒花提取物中寻找在凹坑形成试验中抑制骨吸收的活性成分，并分离出了黄腐酚和葎草酮作为活性成分。特别是葎草酮具有极强的抑制活性，其IC50（50%抑制浓度）值为5.9×10⁻⁹M。
