维生素E对控制不佳的糖尿病患者的果糖胺和糖化血红蛋白水平均无影响。
Vitamin E modifies neither fructosamine nor HbA1c levels in poorly controlled diabetes.
作者信息
Gómez-Pérez F J, Valles-Sanchez V E, López-Alvarenga J C, Choza-Romero R, Ibarra Pascuali J J, González Orellana R, Pérez Ortiz O B, Rodríguez Padilla E G, Aguilar Salinas C A, Rull J A
机构信息
Department of Diabetes and Lipid Metabolism, Instituto Nacional de la Nutrición Salvador Zubirán, México, D.F.
出版信息
Rev Invest Clin. 1996 Nov-Dec;48(6):421-4.
OBJECTIVE
To examine the effects of vitamin E on total serum protein glycation (fructosamine), hemoglobin glycation (HbA1c), and serum levels of glucose, total cholesterol, triglycerides, LDL-C, HDL-C, apolipoprotein A1 and apolipoprotein B.
MATERIAL AND METHODS
Sixty poorly controlled diabetic patients were randomly assigned to receive either 1200 mg/day of vitamin E or identical placebo capsules during a two month period following a double blind cross-over design with a four week wash-out period between regimens.
RESULTS
Seven patients were excluded from the study because of reasons not related to the medication. In the remaining 53 patients, the levels of serum glucose, fructosamine, HbA1c, total cholesterol, HDL-C, LDL-C, Apo A1 and Apo B did not vary significantly with vitamin E as compared with placebo.
CONCLUSIONS
No significant effects of vitamin E on any of the parameters evaluated were observed in poorly controlled diabetic patients.
目的
研究维生素E对血清总蛋白糖基化（果糖胺）、血红蛋白糖基化（糖化血红蛋白HbA1c）以及血清葡萄糖、总胆固醇、甘油三酯、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、载脂蛋白A1和载脂蛋白B水平的影响。
材料与方法
60例血糖控制不佳的糖尿病患者，按照双盲交叉设计，在两个月的时间里随机分为两组，分别服用1200毫克/天的维生素E或相同的安慰剂胶囊，两组治疗方案之间有四周的洗脱期。
结果
7例患者因与药物无关的原因被排除在研究之外。在其余53例患者中，与安慰剂相比，维生素E对血清葡萄糖、果糖胺、HbA1c、总胆固醇、HDL-C、LDL-C、载脂蛋白A1和载脂蛋白B水平无显著影响。
结论
在血糖控制不佳的糖尿病患者中，未观察到维生素E对所评估的任何参数有显著影响。
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