Diaz M N, O'Neill T W, Silman A J
ARC Epidemiology Research Unit, University of Manchester, UK.
Bone. 1997 Feb;20(2):145-9. doi: 10.1016/s8756-3282(96)00331-6.
There are few data exploring clustering of osteoporotic fractures within families. The aim of this study was to determine the influence of maternal and paternal history of hip fracture on the risk of vertebral deformity. 12,816 men and women aged 50 to 75 years were recruited from population based sampling frames across Europe. Subjects were invited to attend by letter of invitation for an interviewer administered questionnaire and lateral spinal radiographs. Vertebral deformity was defined morphometrically using the McCloskey-Kanis method. 6.4% of men and 7.1% of women reported that their mother had suffered a hip fracture, while 1.7% of both men and women reported that their father had suffered a hip fracture. A maternal history of hip fracture was associated with a modest increased risk of vertebral deformity in men [odds ratio (OR) 1.3, 95% confidence interval (CI) 1.0-1.8], the risk being greater among those aged 65 years and over (OR = 1.5; 95% CI 1.0-2.4) and in those from low prevalence areas. There was no increased risk in women. Paternal history of hip fracture was not associated with vertebral deformity in either sex. In conclusion, maternal history of hip fracture appears to be a risk factor for vertebral deformity, particularly in men.
很少有数据探讨骨质疏松性骨折在家族中的聚集情况。本研究的目的是确定父母髋部骨折病史对椎体畸形风险的影响。从欧洲各地基于人群的抽样框架中招募了12,816名年龄在50至75岁之间的男性和女性。通过邀请函邀请受试者参加由访员管理的问卷调查和脊柱侧位X光片检查。椎体畸形采用麦克洛斯基-卡尼斯方法进行形态学定义。6.4%的男性和7.1%的女性报告其母亲曾发生髋部骨折，而1.7%的男性和女性报告其父亲曾发生髋部骨折。母亲有髋部骨折病史与男性椎体畸形风险适度增加相关[比值比（OR）1.3，95%置信区间（CI）1.0 - 1.8]，在65岁及以上人群（OR = 1.5；95% CI 1.0 - 2.4）以及低患病率地区人群中风险更高。女性中未观察到风险增加。父亲有髋部骨折病史与男女两性的椎体畸形均无关联。总之，母亲有髋部骨折病史似乎是椎体畸形的一个危险因素，尤其是在男性中。
