Thörig L, Thompson J, Eulderink F
Infect Immun. 1977 Sep;17(3):504-9. doi: 10.1128/iai.17.3.504-509.1977.
The effect of warfarin treatment on an experimental Staphylococcus epidermidis endocarditis was studied. Warfarin was found to affect both the induction and course of the infection of catheter-induced endocardial vegetations. In warfarin-treated rabbits, larger bacterial inocula were needed to induce an infection, and the degree of infection of the vegetations was also significantly lower, eventually resulting in the total elimination of the bacteria from the vegetations. Thus, warfarin treatment seems to have an inhibitory effect on the induction and development of an S. epidermidis infection of the endocardium. The results differ from previous findings in studies done with Streptococcus anguis, where warfarin was found to have no effect on the induction or course of the infection of endocardial vegetations, which suggests that different mechanisms are involved in the pathogenesis of endocarditis caused by these two species of bacteria.
研究了华法林治疗对实验性表皮葡萄球菌心内膜炎的影响。发现华法林对导管诱导的心内膜赘生物感染的诱导和病程均有影响。在接受华法林治疗的兔子中，诱导感染需要更大的细菌接种量，并且赘生物的感染程度也显著降低，最终导致细菌从赘生物中完全清除。因此，华法林治疗似乎对表皮葡萄球菌心内膜感染的诱导和发展具有抑制作用。这些结果与先前用anguis链球菌进行的研究结果不同，在该研究中发现华法林对心内膜赘生物感染的诱导或病程没有影响，这表明这两种细菌引起的心内膜炎发病机制涉及不同的机制。
