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Evidence for a role for DNA polymerase beta in mammalian meiosis.DNA聚合酶β在哺乳动物减数分裂中作用的证据。
Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1327-31. doi: 10.1073/pnas.94.4.1327.
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DNA polymerase beta is critical for mouse meiotic synapsis.DNA 聚合酶β对于小鼠减数分裂联会至关重要。
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Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes.DNA损伤后体细胞中哺乳动物Rad51重组蛋白的核灶及其在联会复合体中的定位。
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PEX10, SIRPA-SIRPG, and SOX5 gene polymorphisms are strongly associated with nonobstructive azoospermia susceptibility.PEX10、SIRPA-SIRPG 和 SOX5 基因多态性与非梗阻性无精子症易感性密切相关。
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本文引用的文献

1
Meiosis: how could it work?减数分裂：它是如何运作的？
Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8167-74. doi: 10.1073/pnas.93.16.8167.
2
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over.小鼠Mlh1在DNA错配修复及减数分裂交叉互换中的作用。
Nat Genet. 1996 Jul;13(3):336-42. doi: 10.1038/ng0796-336.
3
DNA polymerases alpha and beta are required for DNA repair in an efficient nuclear extract from Xenopus oocytes.非洲爪蟾卵母细胞的高效核提取物中，DNA修复需要DNA聚合酶α和β。
J Biol Chem. 1996 Jun 7;271(23):13816-20. doi: 10.1074/jbc.271.23.13816.
4
Presynaptic association of Rad51 protein with selected sites in meiotic chromatin.Rad51蛋白在减数分裂染色质中与选定位点的突触前关联。
Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5920-4. doi: 10.1073/pnas.93.12.5920.
5
Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes.哺乳动物泛素结合酶Ubc9与Rad51重组蛋白相互作用，并定位于联会复合体中。
Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2958-63. doi: 10.1073/pnas.93.7.2958.
6
Dominant negative rat DNA polymerase beta mutants interfere with base excision repair in Saccharomyces cerevisiae.显性负性大鼠DNA聚合酶β突变体干扰酿酒酵母中的碱基切除修复。
J Bacteriol. 1996 Feb;178(3):656-61. doi: 10.1128/jb.178.3.656-661.1996.
7
Requirement of mammalian DNA polymerase-beta in base-excision repair.碱基切除修复中哺乳动物DNA聚合酶β的需求
Nature. 1996 Jan 11;379(6561):183-6. doi: 10.1038/379183a0.
8
In situ detection of DNA-metabolizing enzymes following polyacrylamide gel electrophoresis.聚丙烯酰胺凝胶电泳后DNA代谢酶的原位检测
Methods Enzymol. 1993;218:587-609. doi: 10.1016/0076-6879(93)18043-c.
9
Yeast open reading frame YCR14C encodes a DNA beta-polymerase-like enzyme.酵母开放阅读框YCR14C编码一种DNAβ聚合酶样酶。
Nucleic Acids Res. 1993 Nov 25;21(23):5301-7. doi: 10.1093/nar/21.23.5301.
10
The yeast Saccharomyces cerevisiae DNA polymerase IV: possible involvement in double strand break DNA repair.酿酒酵母DNA聚合酶IV：可能参与双链断裂DNA修复。
Nucleic Acids Res. 1994 Aug 11;22(15):3011-7. doi: 10.1093/nar/22.15.3011.

DNA聚合酶β在哺乳动物减数分裂中作用的证据。

Evidence for a role for DNA polymerase beta in mammalian meiosis.

作者信息

Plug A W, Clairmont C A, Sapi E, Ashley T, Sweasy J B

机构信息

Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.

出版信息

Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1327-31. doi: 10.1073/pnas.94.4.1327.

DOI:10.1073/pnas.94.4.1327
PMID:9037052
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC19790/
Abstract

DNA polymerase beta (pol beta) is an enzyme possessing both polymerase and deoxyribose phophatase activities. Although pol beta is not believed to participate in the replication of genomic DNA, several studies have indicated a role for pol beta in DNA repair. The high level of expression of pol beta in mouse and rat testes raises the possibility that pol beta participates in mammalian meiosis. Using antibody localization, we detect foci that stain with pol beta antisera at discrete sites along homologous chromosomes as they synapse and progress through prophase of meiosis I. These data suggest that pol beta participates in meiotic events associated with synapsis and recombination.

摘要

DNA聚合酶β（polβ）是一种兼具聚合酶和脱氧核糖磷酸酶活性的酶。尽管一般认为polβ不参与基因组DNA的复制，但多项研究表明polβ在DNA修复中发挥作用。polβ在小鼠和大鼠睾丸中的高表达水平增加了其参与哺乳动物减数分裂的可能性。利用抗体定位技术，我们在同源染色体联会并进入减数分裂I前期时，沿着同源染色体的离散位点检测到被polβ抗血清染色的病灶。这些数据表明polβ参与了与联会和重组相关的减数分裂事件。