Lindsey Scott F, Byrnes Diana M, Eller Mark S, Rosa Ashley M, Dabas Nitika, Escandon Julia, Grichnik James M
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
J Skin Cancer. 2013;2013:190109. doi: 10.1155/2013/190109. Epub 2013 Jun 12.
Melanomas demonstrate chromosomal instability (CIN). In fact, CIN can be used to differentiate melanoma from benign nevi. The exact molecular mechanisms that drive CIN in melanoma have yet to be fully elucidated. Cancer/testis antigens are a unique group of germ cell proteins that are found to be primarily expressed in melanoma as compared to benign nevi. The abnormal expression of these germ cell proteins, normally expected only in the testis and ovaries, in somatic cells may lead to interference with normal cellular pathways. Germ cell proteins that may be particularly critical in CIN are meiosis proteins. Here, we review pathways unique to meiosis with a focus on how the aberrant expression of meiosis proteins in normal mitotic cells "meiomitosis" could impact chromosomal instability in melanoma and other cancers.
黑色素瘤表现出染色体不稳定（CIN）。事实上，CIN可用于区分黑色素瘤和良性痣。驱动黑色素瘤中CIN的确切分子机制尚未完全阐明。癌胚抗原是一组独特的生殖细胞蛋白，与良性痣相比，主要在黑色素瘤中表达。这些通常仅在睾丸和卵巢中表达的生殖细胞蛋白在体细胞中的异常表达可能会干扰正常细胞通路。在CIN中可能特别关键的生殖细胞蛋白是减数分裂蛋白。在此，我们回顾减数分裂特有的通路，重点关注正常有丝分裂细胞中减数分裂蛋白的异常表达（“减数有丝分裂”）如何影响黑色素瘤和其他癌症中的染色体不稳定。
